LEADER 05108nam 22006375 450 001 9910254050703321 005 20200702052549.0 024 7 $a10.1007/978-3-319-45791-8 035 $a(CKB)3710000000892257 035 $a(DE-He213)978-3-319-45791-8 035 $a(MiAaPQ)EBC4710259 035 $a(PPN)196324424 035 $a(EXLCZ)993710000000892257 100 $a20161004d2016 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBacteriophage Applications - Historical Perspective and Future Potential /$fby Jessica Nicastro, Shirley Wong, Zahra Khazaei, Peggy Lam, Jonathan Blay, Roderick A. Slavcev 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (VII, 82 p.) 225 1 $aSpringerBriefs in Biochemistry and Molecular Biology,$x2211-9353 311 $a3-319-45789-6 311 $a3-319-45791-8 320 $aIncludes bibliographical references at the end of each chapters. 327 $a1. Introduction: What are Bacteriophage: a. Discovery and early phage work (including work with bacterial genetics, phage display, and phage therapy) -- b. Bacteriophage pathogenesis and host range -- c. Bacteriophage growth dynamics -- d. Bacteriophage pharmacokinetics( including mammalian host tolerance ) -- 2. Applications with Bacteriophage: a. Phage Therapy -- i. Past ? why phage therapy was unsuccessful in the past and what can (and is currently) being done to improve the system -- ii. Present /Future ? current research objectives and future considerations -- Host range and how it can be expanded -- Lethal agent delivery systems (bacteriocidial) -- Lethality without lysis -- b. Phage Vaccines and Phage Immunostimulation -- i. Mammalian immune response to phage -- ii. Phage vaccine delivery vehicles -- iii. Phage Immunotherapy -- c. Phage as Delivery Vehicles: i. Phage for gene delivery -- Phage display for specific cell targeting -- Considerations for use and benefits in comparison to current systems -- ii. Phage as Drug Carriers -- Selectivity and cell attachment -- Phage T2 as a potential cancer therapeutic -- Phage for delivery to the brain and CNS (including current work with Alzheimer?s and drug addictions ) -- d. Phage for Bacterial Detection: i. History of Phage bacterial detection -- ii. Methods (replication assays, conjugation with bioluminescence, labelling etc. ) -- iii. Potential uses in healthcare and industry -- e. Phage for the targeting of Biofilms -- i. Phage candidates and important bacterial targets -- ii. History and potential uses in healthcare and industry -- f. Phage device coatings: i. Current phage coating practices and research -- ii. Callenges (notably phage orientation) -- iii. methods to overcome these challenges. 330 $aThis book explores key applications of phage biotechnology and reviews recent advances in phage display technologies. The applications covered were selected on the basis of their significance and representativeness in the field. The small size and enormous diversity of bacteriophages make them ideal candidates for numerous applications across many industries. Since the discovery of phages and the advent of phage display systems, considerable attention has been focused on the development of novel therapeutic and industrial applications. Recent studies combine the genomic flexibility of phages with phage display systems in order to generate modified phages for targeted delivery. 410 0$aSpringerBriefs in Biochemistry and Molecular Biology,$x2211-9353 606 $aBiochemical engineering 606 $aCombinatorial chemistry 606 $aGene expression 606 $aBiochemical Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/C12029 606 $aCombinatorial Libraries$3https://scigraph.springernature.com/ontologies/product-market-codes/L15040 606 $aGene Expression$3https://scigraph.springernature.com/ontologies/product-market-codes/B12010 615 0$aBiochemical engineering. 615 0$aCombinatorial chemistry. 615 0$aGene expression. 615 14$aBiochemical Engineering. 615 24$aCombinatorial Libraries. 615 24$aGene Expression. 676 $a576.6482 700 $aNicastro$b Jessica$4aut$4http://id.loc.gov/vocabulary/relators/aut$01061403 702 $aWong$b Shirley$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aKhazaei$b Zahra$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aLam$b Peggy$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aBlay$b Jonathan$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aSlavcev$b Roderick A$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910254050703321 996 $aBacteriophage Applications - Historical Perspective and Future Potential$92518739 997 $aUNINA