LEADER 03922nam 22006735 450 001 9910254047703321 005 20200702144344.0 010 $a3-319-39926-8 024 7 $a10.1007/978-3-319-39926-3 035 $a(CKB)3710000000734984 035 $a(DE-He213)978-3-319-39926-3 035 $a(MiAaPQ)EBC4568533 035 $a(PPN)194379213 035 $a(EXLCZ)993710000000734984 100 $a20160623d2016 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aNovel Therapeutic Approaches to the Treatment of Parkinson?s Disease $eAn Overview and Update /$fedited by Corey R. Hopkins 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (VII, 151 p. 20 illus., 10 illus. in color.) 225 1 $aTopics in Medicinal Chemistry,$x1862-2461 ;$v18 311 $a3-319-39924-1 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aAdenosine A2A Receptor Antagonists -- Targeting ?-Synuclein as a Parkinson?s Disease Therapeutic -- Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors. 330 $aMedicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors. 410 0$aTopics in Medicinal Chemistry,$x1862-2461 ;$v18 606 $aMedicinal chemistry 606 $aMedical biochemistry 606 $aProteins  606 $aMolecular biology 606 $aNeurochemistry 606 $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000 606 $aMedical Biochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/H35005 606 $aReceptors$3https://scigraph.springernature.com/ontologies/product-market-codes/L14110 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aNeurochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/B18010 615 0$aMedicinal chemistry. 615 0$aMedical biochemistry. 615 0$aProteins . 615 0$aMolecular biology. 615 0$aNeurochemistry. 615 14$aMedicinal Chemistry. 615 24$aMedical Biochemistry. 615 24$aReceptors. 615 24$aMolecular Medicine. 615 24$aNeurochemistry. 676 $a616.83306 702 $aHopkins$b Corey R$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910254047703321 996 $aNovel Therapeutic Approaches to the Treatment of Parkinson?s Disease$92545270 997 $aUNINA