LEADER 03304nam 22005895 450 001 9910254025903321 005 20200705061557.0 010 $a3-319-20040-2 024 7 $a10.1007/978-3-319-20040-8 035 $a(CKB)3710000000711712 035 $a(DE-He213)978-3-319-20040-8 035 $a(MiAaPQ)EBC4533798 035 $a(PPN)194074145 035 $a(EXLCZ)993710000000711712 100 $a20160527d2016 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aComputational Modelling of the Human Islet Amyloid Polypeptide /$fby Katrine Kirkeby Skeby 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (XVI, 118 p. 58 illus., 47 illus. in color.) 225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 300 $a"Doctoral thesis accepted by the Aarhus University, Aarhus C, Denmark." 311 $a3-319-20039-9 320 $aIncludes bibliographical references at the end of each chapters. 327 $aAmyloid and Amyloid Fibrils -- Computational Theory -- Imaging Agent Binding to Amyloid Protofibrils -- Determining the Aggregation Prone Structure of hiAPP -- Effect of Terminal Capping on Aggregation of Peptide Fragments -- Coarse Grained Study of Amyloid Protofibril Aggregation -- Conclusion and Perspectives. 330 $aThis thesis offers readers a comprehensive introduction to amyloid proteins and the computational methods used with them. Katrine Skeby critically assesses and compares both the literature and the experiments performed by other researchers, which further elevates the quality and relevance of her own work. Amyloid proteins are highly complex, and this research provides unparalleled insights, especially with regard to the origin of cytotoxicity and to developing technologies for early detection, revealing in detail the molecular mechanisms behind hIAPP behavior. Several studies within the thesis answer difficult questions which promote future research into the properties of amyloid proteins. 410 0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 606 $aPharmaceutical chemistry 606 $aCheminformatics 606 $aBioorganic chemistry 606 $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000 606 $aComputer Applications in Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C13009 606 $aBioorganic Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C19010 615 0$aPharmaceutical chemistry. 615 0$aCheminformatics. 615 0$aBioorganic chemistry. 615 14$aMedicinal Chemistry. 615 24$aComputer Applications in Chemistry. 615 24$aBioorganic Chemistry. 676 $a540 700 $aSkeby$b Katrine Kirkeby$4aut$4http://id.loc.gov/vocabulary/relators/aut$01059821 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910254025903321 996 $aComputational Modelling of the Human Islet Amyloid Polypeptide$92508528 997 $aUNINA