LEADER 03589oam 2200697 450 001 9910150236503321 005 20230725031439.0 010 $a1-283-11482-8 010 $a9786613114822 010 $a0-273-73445-8 035 $a(CKB)2670000000093952 035 $a(SSID)ssj0000528399 035 $a(PQKBManifestationID)12192615 035 $a(PQKBTitleCode)TC0000528399 035 $a(PQKBWorkID)10549172 035 $a(PQKB)10037793 035 $a(MiAaPQ)EBC5174117 035 $a(MiAaPQ)EBC5175758 035 $a(MiAaPQ)EBC5831841 035 $a(MiAaPQ)EBC5138742 035 $a(MiAaPQ)EBC6398897 035 $a(Au-PeEL)EBL5138742 035 $a(CaONFJC)MIL311482 035 $a(OCoLC)1015875556 035 $a(EXLCZ)992670000000093952 100 $a20210426d2011 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aFT guide to business coaching /$fAnne Scoular 205 $a1st ed. 210 1$aHarlow, England ;$aNew York, United States :$cFinancial Times/Prentice Hall,$d[2011] 210 4$d©2011 215 $a1 online resource (238 pages) $cillustrations, tables 225 1 $aFinancial Times guides 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a0-273-73444-X 320 $aIncludes bibliographical references and index. 327 $aIntroduction : the business of coaching -- The coaches -- Do you have what it takes? -- Developing your coaching : first steps -- Building your basic coaching skills : the 'big five' -- Building coaching skills : the different approaches -- Deepening coaching skills : working with individual difference -- Advanced coaching : from individuals to groups -- Advanced coaching : coaching and career transitions -- Advanced coaching : motivation and change -- Why it works -- Building a freelance coaching business. 330 $aThe FT Guide to Business Coaching shows you everything you need to know about becoming a business coach, from how to find out if you've got what it takes, through the basic tools and models that really work. This book gives you a step-by-step guide to the tools, the market knowledge and the crucial new techniques from psychology you need to become an exceptional business coach. Clear, compelling and comprehensive, covering classic and fresh material from both business and psychology, this is the first book to cover both the critical elements of world-class business coaching. This book takes you through a tried and trusted process developed specifically for senior business leaders. It will help you: Know when to coach and when to lead. Build powerful listening skills. Get to grips with the most useful and up-to-the minute coaching tools and psychological techniques. Calculate if - and crucially, how - you can make a living as a business coach. Decide if, how and when to go for accreditation as a coach. 410 0$aFinancial times guides. 517 3 $aGuide to business coaching 517 3 $aBusiness coaching 606 $aLeadership$xStudy and teaching 606 $aExecutives$xTraining of 606 $aExecutive coaching 615 0$aLeadership$xStudy and teaching. 615 0$aExecutives$xTraining of. 615 0$aExecutive coaching. 676 $a658.407124 686 $a85.08$2bcl 700 $aScoular$b Anne$01238564 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bUtOrBLW 906 $aBOOK 912 $a9910150236503321 996 $aFT guide to business coaching$92874373 997 $aUNINA LEADER 04572nam 22006735 450 001 9910254023703321 005 20200704082049.0 010 $a981-10-0657-1 024 7 $a10.1007/978-981-10-0657-9 035 $a(CKB)3710000000602246 035 $a(EBL)4415589 035 $a(SSID)ssj0001653295 035 $a(PQKBManifestationID)16433721 035 $a(PQKBTitleCode)TC0001653295 035 $a(PQKBWorkID)14983096 035 $a(PQKB)10780484 035 $a(DE-He213)978-981-10-0657-9 035 $a(MiAaPQ)EBC4415589 035 $a(PPN)192222996 035 $a(EXLCZ)993710000000602246 100 $a20160219d2016 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAnti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II) $eThiol ?Switch-on? Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents /$fby Taotao Zou 205 $a1st ed. 2016. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2016. 215 $a1 online resource (175 p.) 225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 300 $aDescription based upon print version of record. 311 $a981-10-0656-3 320 $aIncludes bibliographical references. 327 $aIntroduction -- Experimental Section -- Gold(III) Complexes Containing N-Heterocyclic Carbene Ligand Serve as Dual Fluorescent Thiol ?Switch-on? Probe and Anti-Cancer Agent -- A Binuclear Gold(I) Complex with Mixed Bridging Diphosphine and Bis(N-Heterocyclic Carbene) Ligands Shows Favorable Thiol Reactivity and Effectively Inhibits Tumor Growth and Angiogenesis in Vivo -- Luminescent Organoplatinum(II) Complexes Containing Bis(N-Heterocyclic Carbene) Ligands Selectively Target Endoplasmic Reticulum and Induce Potent Phototoxicity -- Summary and Evaluation. 330 $aThis thesis focuses on the development of gold- and non-classical platinum-based anti-cancer agents that display distinctively different anti-cancer mechanisms compared to the commonly used cisplatin. These metal complexes contain N-heterocyclic carbene (NHC) ligands which are able to form strong M-C(NHC) bonds, conferring high stability and favorable lipophilicity, reactivity and binding specificity of metal complexes on biomolecules. The author demonstrates significant advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. Detailed chemical synthesis, in vitro and/or in vivo anti-cancer activities are clearly presented including: (i) a class of Au(III) complexes containing a highly fluorescent N^N^N ligand and NHC ligand that simultaneously act as fluorescent thiol ?switch-on? probes and anti-cancer agents; (ii) a dinuclear gold(I) complex with a mixed diphosphine and bis(NHC) ligand displaying favorable stability and showing significant inhibition of tumor growth in two independent mice models with no observable side effects; and (iii) a panel of stable luminescent cyclometalated platinum(II) complexes exhibiting high specificity to localize to the endoplasmic reticulum (ER) domain, inducing ER stress and cell apoptosis. These works highlight the clinical potential that gold and platinum complexes offer for cancer treatment. 410 0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 606 $aChemistry, Inorganic 606 $aPharmaceutical chemistry 606 $aMolecular biology 606 $aCancer$xResearch 606 $aInorganic Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C16008 606 $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 615 0$aChemistry, Inorganic. 615 0$aPharmaceutical chemistry. 615 0$aMolecular biology. 615 0$aCancer$xResearch. 615 14$aInorganic Chemistry. 615 24$aMedicinal Chemistry. 615 24$aMolecular Medicine. 615 24$aCancer Research. 676 $a540 700 $aZou$b Taotao$4aut$4http://id.loc.gov/vocabulary/relators/aut$01062282 906 $aBOOK 912 $a9910254023703321 996 $aAnti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)$92524149 997 $aUNINA