LEADER 03686nam 22005775 450 001 9910253959803321 005 20200701213159.0 010 $a3-319-68929-0 024 7 $a10.1007/978-3-319-68929-6 035 $a(CKB)4340000000223469 035 $a(DE-He213)978-3-319-68929-6 035 $a(MiAaPQ)EBC5161640 035 $a(PPN)221252010 035 $a(EXLCZ)994340000000223469 100 $a20171125d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aEmerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity /$fedited by Akihiko Yoshimura 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (VIII, 267 p.) 225 1 $aCurrent Topics in Microbiology and Immunology,$x0070-217X ;$v410 311 $a3-319-68928-2 320 $aIncludes bibliographical references at the end of each chapters. 327 $aRegulatory T cells: molecular and cellular basis for immunoregulation -- Overview of LAG-3- expressing, IL-10-producing regulatory T cells -- Regulatory Dendritic Cells -- Role of PD-1 in immunity and diseases -- CTLA-4, an essential immune-checkpoint for T cell activation -- Tim-3, Lag-3, and TIGIT -- SOCS1: regulator of T cells in autoimmunity and cancer -- Mining the complex family of protein tyrosine phosphatases for checkpoint regulators in immunity -- Immune regulation by ubiquitin tagging as checkpoint code -- MicroRNA in Immune Regulation. 330 $aThis volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to ?molecules and cells that negatively regulate T-cell activation?. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases. Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike. 410 0$aCurrent Topics in Microbiology and Immunology,$x0070-217X ;$v410 606 $aImmunology 606 $aCancer research 606 $aCell biology 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 615 0$aImmunology. 615 0$aCancer research. 615 0$aCell biology. 615 14$aImmunology. 615 24$aCancer Research. 615 24$aCell Biology. 676 $a616.0795 702 $aYoshimura$b Akihiko$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910253959803321 996 $aEmerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity$92084607 997 $aUNINA