LEADER 04196nam 22006015 450 001 9910253955303321 005 20231002172342.0 010 $a3-319-58338-7 024 7 $a10.1007/978-3-319-58338-9 035 $a(CKB)4100000001040458 035 $a(DE-He213)978-3-319-58338-9 035 $a(MiAaPQ)EBC5143344 035 $a(PPN)221253599 035 $a(EXLCZ)994100000001040458 100 $a20171110d2017 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aChromogranins: from Cell Biology to Physiology and Biomedicine /$fedited by Tommaso Angelone, Maria Carmela Cerra, Bruno Tota 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (IX, 267 p. 16 illus., 4 illus. in color.) 225 1 $aUNIPA Springer Series,$x2366-7516 311 $a3-319-58337-9 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aChromaffin cells and Granins: History and Perspectives -- The extended granin family: structure, function, and biomedical implications -- CgA and CgB in granule secretion -- Proteolytic processing of CgA and CgB/Antimicrobial properties of Chromogranins -- Chromogranins and inositol 1,4,5-trisphosphate-dependent Ca2+-signaling -- CgA in angiogenesis and tumor biology -- Full length CgA: a multifaceted protein in cardiovascular health and disease -- Physio-pharmacological aspects of three Chromogranin A-derived peptides: Vasostatin, Catestatin, and Serpinin -- Comparative aspects of CgA-derived peptides in cardiac homeostasis -- Molecular and cellular mechanisms of action of CgA-derived peptides in cardiomyocytes and endothelial cells -- CgA-derived peptides in pre- and post-conditioning cardioprotection -- Catestatin in physiopathology -- Serpinin: from biosynthesis to cell biology and physiopathology -- Pancreastatin and metabolism -- Chromogranins and the quantum release of catecholamines. 330 $aThe volume is designed to provide an integrated overview of the results from the last fifteen years of research on Chromogranins in relation to cell biology, physiology and biomedicine. The different chapters highlight novel activities of these proteins, including their role in granule biogenesis, hormone co-storage, stimulus-processing-secretion coupling, autonomic sympathetic/parasympathetic balance, immune and cardiocirculatory function, and the response to stress. Biomedical aspects are also illustrated with focus on the prognostic and diagnostic significance of Chromogranin in the presence of tumors, cardiovascular diseases and inflammatory conditions. The volume is of interest for laboratory and clinical scientists, PhD and Post-doc students that will be inspired to go deep inside the molecular, biochemical, physiological, pharmacological and clinical aspects of these fascinating multifaceted proteins. 410 0$aUNIPA Springer Series,$x2366-7516 606 $aHuman physiology 606 $aAnimal physiology 606 $aMolecular biology 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 606 $aAnimal Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L33030 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 615 0$aHuman physiology. 615 0$aAnimal physiology. 615 0$aMolecular biology. 615 14$aHuman Physiology. 615 24$aAnimal Physiology. 615 24$aMolecular Medicine. 676 $a572.68 702 $aAngelone$b Tommaso$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aCerra$b Maria Carmela$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aTota$b Bruno$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910253955303321 996 $aChromogranins: from Cell Biology to Physiology and Biomedicine$92264748 997 $aUNINA