LEADER 06021nam 22005775 450 001 9910253948103321 005 20220816060633.0 010 $a3-319-63245-0 024 7 $a10.1007/978-3-319-63245-2 035 $a(CKB)4100000000882313 035 $a(DE-He213)978-3-319-63245-2 035 $a(MiAaPQ)EBC5108753 035 $a(PPN)220125198 035 $a(EXLCZ)994100000000882313 100 $a20171018d2017 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aPulmonary Vasculature Redox Signaling in Health and Disease /$fedited by Yong-Xiao Wang 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (XXI, 422 p. 57 illus., 41 illus. in color.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v967 311 $a3-319-63244-2 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aChapter1. Adventitial Fibroblast Nox4 Expression and ROS Signaling in Pulmonary Arterial Hypertension -- Chapter2. Role of Transcription Factors in Pulmonary Artery Smooth Muscle Cells: An important Link to Hypoxic Pulmonary Hypertension -- Chapter3. Molecular Basis of Nitrative Stress in the Pathogenesis of Pulmonary Hypertension -- Chapter4. Pentose Shunt, Glucose-6-phosphate dehydrogenase and NADPH redox, and Stem cells in Pulmonary Hypertension -- Chapter5. Redox regulation of the superoxide dismutases SOD3 and SOD2 in the pulmonary circulation. ? Chapter6. A Brief Overview of Nitric Oxide and Reactive Oxygen Species Signaling In Hypoxia-Induced Pulmonary Hypertension -- Chapter7. Altered redox balance in the development of chronic hypoxia- induced pulmonary hypertension -- Chapter8. ROS signaling in the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) -- Chapter9. Redox-dependent calpain signaling in airway and pulmonary vascular and remodeling in COPD -- Chapter10. Natural antioxidants as potential therapy, and a promising role for melatonin against pulmonary hypertension -- Chapter11. Effects of Hyperoxia on the Developing Airway and Pulmonary Vasculature -- Chapter12. Lung ischemia/reperfusion injury ? the role of reactive oxygen species -- Chapter13. Redox Mechanisms Influencing cGMP Signaling in Pulmonary Vascular Physiology and Pathophysiology -- Chapter14. Metabolic Reprogramming and Redox Signaling in Pulmonary Hypertension -- Chapter15. Hydrogen sulfide as an O2 sensor: a critical analysis -- Chapter16. Redox Signaling and Persistent Pulmonary Hypertension of the Newborn -- Chapter17. Crosstalk between mitochondrial reactive oxygen species and sarcoplasmic reticulum calcium in pulmonary arterial smooth muscle cells -- Chapter18. Endothelial Cell Reactive Oxygen Species and Ca2+ Signaling in Pulmonary Hypertension -- Chapter19. Redox signaling in the right ventricle -- Chapter20. Hypoxia and Local Inflammation in Pulmonary Artery Structure and Function -- Chapter21. From physiological redox signalling to oxidant stress -- Chapter22. Emerging Role of MicroRNAs and Long Noncoding RNAs in Healthy and Diseased Lung -- Chapter23. Techniques for Detecting Reactive Oxygen Species in Pulmonary Vasculature Redox Signaling -- Chapter24. Mitochondrial and metabolic drivers of pulmonary vascular endothelial dysfunction in pulmonary hypertension -- Chapter25. Subcellular Redox Signaling -- Chapter26. Reactive oxygen species in COPD-related vascular remodeling. 330 $aThe main goal of this book is to form a high-quality platform in which well-known and emerging pioneering basic, translational and clinical scientists can present their latest, exciting findings in the studies of redox signaling in the pulmonary vasculature. Content from outstanding investigators with unique expertise and skills of molecular and cell biology, biochemistry, physiology, pharmacology, biophysics, biotechnology and medicine will update our current out-of-date concepts with new knowledge. Rapidly increasing scientific studies have gathered a large volume of novel and important information on redox signaling in healthy and diseased pulmonary vasculature. This volume covers the need for a cohesive book to display state-of-the-art advances in the field.    The second major aim of this book is to help direct future research. Redox signaling is a major molecular process involved in almost every physiologic cellular response in the pulmonary vasculature including energy metabolism, host defense, gene expression, contraction, proliferation, and migration. Aberrancy in this important signaling pathway leads to a critical role in the development of nearly all pulmonary diseases, such as pulmonary hypertension, cor pulmonale, pulmonary edema, and vasculitis, among others.  . 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v967 606 $aHuman physiology 606 $aRespiratory organs$xDiseases 606 $aCell physiology 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 606 $aPneumology/Respiratory System$3https://scigraph.springernature.com/ontologies/product-market-codes/H33134 606 $aCell Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L33010 615 0$aHuman physiology. 615 0$aRespiratory organs$xDiseases. 615 0$aCell physiology. 615 14$aHuman Physiology. 615 24$aPneumology/Respiratory System. 615 24$aCell Physiology. 676 $a572.53 702 $aWang$b Yong-Xiao$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910253948103321 996 $aPulmonary Vasculature Redox Signaling in Health and Disease$92133984 997 $aUNINA