LEADER 03611nam 22005775 450 001 9910253946403321 005 20200710083104.0 010 $a3-319-64526-9 024 7 $a10.1007/978-3-319-64526-1 035 $a(CKB)4100000000882319 035 $a(DE-He213)978-3-319-64526-1 035 $a(MiAaPQ)EBC5111847 035 $a(PPN)220121982 035 $a(EXLCZ)994100000000882319 100 $a20171024d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aIgM and Its Receptors and Binding Proteins$b[electronic resource] /$fedited by Hiromi Kubagawa, Peter D. Burrows 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (IX, 117 p. 30 illus., 15 illus. in color.) 225 1 $aCurrent Topics in Microbiology and Immunology,$x0070-217X ;$v408 320 $aIncludes bibliographical references. 327 $aThe appearance and diversification of receptors for IgM during vertebrate evolution. -- Authentic IgM Fc Receptor (Fc?R) -- FCRLA - A resident endoplasmic reticulum protein that associates with multiple immunoglobulin isotypes in B lineage cells -- Specific IgM and regulation of antibody responses -- Role of Natural IgM autoantibodies (IgM- NAA) and IgM anti-leucocyte antibodies (IgM-ALA) in regulating inflammation. 330 $aThis volume reviews the current state of research on the IgM antibody and its multiple receptors and binding proteins. Interactions of the IgM ligands with these molecules are important for protection against infections as a first line of defense, as well as for regulation of immune responses to pathogens and self-antigens. The book includes up-to-date information on: (i) the phylogeny of three IgM-binding receptors [polymeric Ig receptor (pIgR), Fc receptor for both IgA and IgM (Fc?/µR), and Fc receptor for IgM only (FcµR)]; (ii) the lymphocyte-restricted distribution and unique ligand-binding activity of FcµR; (iii) the definition and potential function of Fc receptor-like molecule A (FCRLA) as a resident endoplasmic reticulum protein that binds IgM, but also IgG and IgA; (iv) IgM antibody-mediated enhancement of humoral immune responses, highlighting the importance of complement and its receptors, (v) the numerous important roles of IgM natural antibodies in regulation of inflammation. It is an invaluable resource for researchers and clinicians alike. 410 0$aCurrent Topics in Microbiology and Immunology,$x0070-217X ;$v408 606 $aImmunology 606 $aInfectious diseases 606 $aRheumatology 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aInfectious Diseases$3https://scigraph.springernature.com/ontologies/product-market-codes/H33096 606 $aRheumatology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33170 615 0$aImmunology. 615 0$aInfectious diseases. 615 0$aRheumatology. 615 14$aImmunology. 615 24$aInfectious Diseases. 615 24$aRheumatology. 676 $a616.9706 702 $aKubagawa$b Hiromi$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBurrows$b Peter D$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910253946403321 996 $aIgM and Its Receptors and Binding Proteins$91954759 997 $aUNINA