LEADER 01059nam a22002771i 4500 001 991000721839707536 005 20240708104043.0 008 021025s1958 it er 001|f ita d 035 $ab1204569x-39ule_inst 035 $aARCHE-013549$9ExL 040 $aDip.to Filologia Ling. e Lett.$bita$cA.t.i. Arché s.c.r.l. Pandora Sicilia s.r.l.$dSocioculturale Scs 041 0 $aita 082 04$a853.914$223 100 1 $aManzini, Gianna$083352 245 10$aCara prigione /$cGianna Manzini 260 $aMilano :$bA. Mondadori,$c1958 300 $a368 p. ;$c19 cm 490 1 $aNarratori italiani ;$v51 830 0$aNarratori italiani ;$v51 907 $a.b1204569x$b28-04-17$c01-04-03 912 $a991000721839707536 945 $aLE008 FL.M. IV H 37$g1$iLE008IFM-5600$lle008$o-$pE0.00$q-$rl$s-$t0$u0$v0$w0$x0$y.i12338667$z01-04-03 945 $aLE008 FL.M. V H 37$g1$i2008000142315$lle008$o-$pE0.00$q-$rl$s-$t0$u0$v0$w0$x0$y.i14521763$z23-07-07 996 $aCara prigione$998987 997 $aUNISALENTO 998 $ale008$b01-04-03$cm$da$e-$fita$git$h0$i1 LEADER 02853nam 22004695 450 001 9910253946203321 005 20200704072728.0 010 $a981-10-4971-8 024 7 $a10.1007/978-981-10-4971-2 035 $a(CKB)3710000001631558 035 $a(MiAaPQ)EBC4939364 035 $a(DE-He213)978-981-10-4971-2 035 $a(PPN)203848780 035 $a(EXLCZ)993710000001631558 100 $a20170804d2017 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aNotch Signaling $eImmunity and Cancer /$fedited by Koji Yasutomo 205 $a1st ed. 2017. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2017. 215 $a1 online resource (104 pages) 311 $a981-10-4970-X 320 $aIncludes bibliographical references at the end of each chapters. 327 $aPreface -- Part I Immunology -- Ch1 Notch ligands for lymphocyte development -- Ch2 Notch controls the differentiation and function of cytotoxic CD8 T cells -- Ch3 Notch and myeloid cells -- Ch4 Taking CD4 T cells up a Notch -- Part II Cancer -- Ch5 NOTCH in malignant lymphoma -- Ch6 The two faces of Notch in solid cancers. 330 $aThis book covers the broad area related to Notch-mediated regulation of the immune system and tumorigenesis. Notch signaling was originally identified as a crucial pathway to regulate cell fate choice. Subsequent studies, however, have revealed that Notch regulates many steps of immune cell differentiation or development as well as tumorigenesis of cells. Although there are still many controversial issues regarding the functions or regulatory mechanism of Notch, it is important to summarize all data together in one volume to help facilitate this research area. Also, the studies regarding the functions of Notch in immune cells and tumor cells have motivated researchers and pharmaceutical companies to develop drugs for treating immune-mediated diseases and tumors. Therefore, this book covering the broad area of Notch in immunology and tumorigenesis will be attractive to many researchers including faculty members and postdoctoral fellows in academia and researchers in the pharmaceutical industry. 606 $aImmunology 606 $aCancer$xResearch 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 615 0$aImmunology. 615 0$aCancer$xResearch. 615 14$aImmunology. 615 24$aCancer Research. 676 $a591.19245 702 $aYasutomo$b Koji$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910253946203321 996 $aNotch Signaling$92233538 997 $aUNINA