LEADER 04529nam 22006855 450 001 9910253945803321 005 20230810192256.0 010 $a3-319-64543-9 024 7 $a10.1007/978-3-319-64543-8 035 $a(CKB)4100000000882320 035 $a(DE-He213)978-3-319-64543-8 035 $a(MiAaPQ)EBC5111838 035 $a(PPN)220126968 035 $a(EXLCZ)994100000000882320 100 $a20171024d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCircadian Rhythms and Their Impact on Aging /$fedited by S. Michal Jazwinski, Victoria P Belancio, Steven M Hill 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (XIII, 361 p. 41 illus., 15 illus. in color.) 225 1 $aHealthy Ageing and Longevity,$x2199-9015 ;$v7 311 $a3-319-64542-0 320 $aIncludes bibliographical references and indexes. 330 $aThis book examines the role of circadian rhythms in aging, an emerging area of biology.  Although implicated in aging and longevity for over forty years, the richness of the ways in which the circadian system impacts aging has become evident only more recently.  The circadian system consists of a central pacemaker and a multitude of peripheral clocks, located in most cells throughout the organism. These clocks keep metabolic, physiological, and behavioral patterns in tune with the twenty-four hour day/night cycle and with each other.  Disruptions of the circadian system, such as the presence of light at night, can have profound pathological implications.  The core circadian oscillator consists of a multicomponent transcriptional feedback loop that regulates the periodicity of expression of some ten percent of the genes in the human genome.  This easily explains the broad influence of the circadian system.   The chapters in this volume fall into four sections that follow a brief introduction.  They are written by experts performing the research in this field.  The first section/chapter surveys the operation of the aging circadian system with a focus on melatonin signaling.  In the second section, this theme is amplified through a discussion of the aging lung, bone, and gastrointestinal system.  A section composed of eight chapters explores in detail cellular and molecular mechanisms associated with circadian system aging, in a range of experimental models.  The studies reviewed include genetic, epigenetic, molecular, cell biological, metabolic, and physiologic approaches.  The final section details the effects of sleep disruption on mortality risk in older adults and the effects of physical activity on circadian rhythms in the elderly, adding to the earlier discussion of the potential of chronotherapeutics.   Advanced undergraduates and graduate students will find this book both a suitable introduction and a definitive treatment of the impact of circadian rhythms on aging.  Instructors and researchers in circadian biology and in aging biology will discover this to be a valuable reference work, which brings these fields into juxtaposition and merger.  This volume will contribute to further advances in this important interdisciplinary area. 410 0$aHealthy Ageing and Longevity,$x2199-9015 ;$v7 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aCytology 606 $aGeriatrics 606 $aSocial sciences 606 $aHumanities 606 $aBiomedical Research 606 $aCell Biology 606 $aGeriatrics 606 $aHumanities and Social Sciences 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aCytology. 615 0$aGeriatrics. 615 0$aSocial sciences. 615 0$aHumanities. 615 14$aBiomedical Research. 615 24$aCell Biology. 615 24$aGeriatrics. 615 24$aHumanities and Social Sciences. 676 $a612.022 702 $aJazwinski$b S. Michal$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBelancio$b Victoria P$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aHill$b Steven M$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910253945803321 996 $aCircadian Rhythms and Their Impact on Aging$92233537 997 $aUNINA