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010   $a3-319-59504-0
024 7 $a10.1007/978-3-319-59504-7
035   $a(CKB)3710000001631534
035   $a(MiAaPQ)EBC4939985
035   $a(DE-He213)978-3-319-59504-7
035   $a(PPN)203853423
035   $a(EXLCZ)993710000001631534
100   $a20170807d2017      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $2rdacontent
182   $2rdamedia
183   $2rdacarrier
200 10$aDermal Drug Selection and Development $eAn Industrial Perspective /$fby Lionel Trottet, Howard Maibach, MD
205   $a1st ed. 2017.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017.
215   $a1 online resource (154 pages)
311   $a3-319-59503-2 
320   $aIncludes bibliographical references and index.
327   $aIntroduction -- Choosing the topical drug candidate -- Key factors affecting the efficacy of a topical drug candidate -- Topical vs. Oral/systemic Drug discovery -- Assessing drug concentration in skin -- Assessing Topical efficacy -- Assessing the therapeutic index -- Topical vehicle selection -- Topical drug development strategies -- Topical drug candidate selection criteria and cascade -- Selecting a dermal drug candidate -- Conclusions and perspectives.
330   $aThe authors show how the pharmaceutical industry faces the development of dermal drugs and provide the only book of its kind that describes how the industry develops and selects dermal drugs, complete with the challenges and opportunities of the field. Delivery of drugs through the skin has been an attractive and challenging area for research, and advances in modern technologies have resulted in a larger number of drugs being delivered transdermally, including conventional hydrophobic small molecule drugs, hydrophilic drugs and macromolecules. Offering the perspective from the industrial side of selection and development of drugs, the primary audience is geared towards the pharmaceutical industry but can also offer valuable information to clinicians, compounding pharmacists, and similarly pharmacy students. Dermal Drug Selection and Development covers the scientific gaps that exist in terms of dermal pharmacokinetics and the resulting uncertainty by clinicians when choosing a drug candidate.
606   $aPharmaceutical technology
606   $aDermatology
606   $aPharmaceutical Sciences/Technology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21010
606   $aDermatology$3https://scigraph.springernature.com/ontologies/product-market-codes/H1900X
615  0$aPharmaceutical technology.
615  0$aDermatology.
615 14$aPharmaceutical Sciences/Technology.
615 24$aDermatology.
676   $a615.19
700   $aTrottet$b Lionel$4aut$4http://id.loc.gov/vocabulary/relators/aut$0979499
702   $aMaibach$b MD, Howard$4aut$4http://id.loc.gov/vocabulary/relators/aut
906   $aBOOK
912   $a9910253942303321
996   $aDermal Drug Selection and Development$92233534
997   $aUNINA