LEADER 03797nam 22004815 450 001 9910253942203321 005 20200704120031.0 010 $a3-319-56170-7 024 7 $a10.1007/978-3-319-56170-7 035 $a(CKB)3710000001631521 035 $a(DE-He213)978-3-319-56170-7 035 $a(MiAaPQ)EBC4984425 035 $a(PPN)203851234 035 $a(EXLCZ)993710000001631521 100 $a20170823d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$amGLU Receptors /$fedited by Richard Teke Ngomba, Giuseppe Di Giovanni, Giuseppe Battaglia, Ferdinando Nicoletti 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Humana,$d2017. 215 $a1 online resource (X, 282 p. 28 illus., 26 illus. in color.) 225 1 $aThe Receptors,$x1048-6909 ;$v31 311 $a3-319-56168-5 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $amGlu5 Signalling: A Target for Addiction Therapeutics? -- Supraspinal Metabotropic Glutamate Receptors: An Endogenous Substrate for Alleviating Chronic Pain and Related Affective Disorders -- Metabotropic Glutamate Receptors and Parkinson's Disease: Basic and Preclinical Neuroscience -- Metabotropic Glutamate 2 (mGlu2) Receptors and Schizophrenia Treatment -- mGlu5: A Metabotropic Glutamate Receptor at the Hub of Hippocampal Information Processing, Persistent Synaptic Plasticity and Long-Term Memory -- Neuroprotective Properties of Glutamate Metabotropic Glutamate Receptors in Parkinson?s Disease and Other Brain Disorders -- Structure, Dynamics and Modulation of Metabotropic Glutamate Receptors -- Metabotropic Glutamate Receptor Function in Thalamocortical Circuitry -- Metabotropic Glutamate Receptors in Cancer -- mGlu5 Receptors in Parkinson?s Disease and MPTP-Lesioned Monkeys: Behaviour and Brain Molecular Correlates -- Is There a Future for PAMs of Group I mGluR in Absence Epilepsy? -- Regulation of Hippocampal mGluR-Dependent Long-Term Depression by GluA2-Dependent Cofilin-Mediated Actin Remodeling -- Metabotropic Glutamate Receptors in Amygdala Functions. 330 $aMetabotropic glutamate receptors (mGluRs) are members of the group C family of G-protein-coupled receptors. Eight different mGlu subtypes have been identified and classified into three groups based on amino acid sequence similarity, agonist pharmacology, and the signal transduction pathways to which they couple. They perform a variety of functions in the central and peripheral nervous systems, being involved in learning, memory, anxiety, and the perception of pain. They are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and cerebral cortex, as well as other parts of the brain and peripheral tissues. This volume comprises the latest contributions of experts in the field on the role of mGlu receptor in health and disease, following the 8th International meeting on these receptors. 410 0$aThe Receptors,$x1048-6909 ;$v31 606 $aNeurosciences 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 615 0$aNeurosciences. 615 14$aNeurosciences. 676 $a612.8 702 $aNgomba$b Richard Teke$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aDi Giovanni$b Giuseppe$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBattaglia$b Giuseppe$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aNicoletti$b Ferdinando$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910253942203321 996 $aMGLU Receptors$92215690 997 $aUNINA