LEADER 04193nam 22005895 450 001 9910253941903321 005 20200705052446.0 010 $a3-319-57313-6 024 7 $a10.1007/978-3-319-57313-7 035 $a(CKB)3710000001631522 035 $a(MiAaPQ)EBC4946558 035 $a(DE-He213)978-3-319-57313-7 035 $a(PPN)203850815 035 $a(EXLCZ)993710000001631522 100 $a20170811d2017 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aPharmacology of Mitochondria /$fedited by Harpreet Singh, Shey-Shing Sheu 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (491 pages) $cillustrations 225 1 $aHandbook of Experimental Pharmacology,$x0171-2004 ;$v240 311 $a3-319-57311-X 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aMitochondrial Genetics and Ion Transportation: Nuclear transcription factors in the mitochondria: a new paradigm in cellular transformation -- The mitochondrial permeability transition pore and ATP synthase -- Mitochondrial ion fluxes in health and diseases -- Mitochondrial anion channels -- Pharmacology of mitochondrial potassium channels -- Mitochondrial Ca2+ uniporter complex as promising therapeutic target for human diseases and aging -- Mitochondria in Health and Diseases: Mitochondrial Division in Human Disease -- Mitochondrial cholesterol and the paradox in cell death -- Mitochondrial dysfunction in neuromuscular disorders -- Mitochondrial dynamics in cancer -- The emerging role of mitochondrial targeting in kidney disease -- Mitochondrial dynamics as therapeutic targets for treating cardiac disease -- Mitochondria in Alzheimer´s disease and Diabetes-associated Neurodegeneration -- Leber Hereditary Optic Neuropathy, a mitochondrial disease unique in many ways -- Therapeutic Approaches and Mitochondria: Mitochondrial Variation in Health and Disease -- Bioinformatic methods and resources for integrated mitochondrial physiology -- Nanoparticle based therapeutics for mitochondrial dysfunctions -- Mitochondrial respiratory chain complexes as drugs targets -- Targeting the Mitoflash for the Control of Mitochondrial Functions.-Mitochondrial Antioxidant Therapy: Promise or Delusion?- Roles of mitochondrial ROS generation to protect from further prooxidant situations -- MITO-Porter for mitochondrial delivery and mitochondrial functional analysis -- Toxicity of antiepileptic drugs to mitochondria. 330 $aThis special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. The chapters contributed by leading mitochondrial researchers in the handbook will take us through the novel pharmacological strategies via mitochondria to understand their physiological and pathological role as well as present them as therapeutic targets. 410 0$aHandbook of Experimental Pharmacology,$x0171-2004 ;$v240 606 $aPharmacology 606 $aCardiology 606 $aNeurosciences 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aCardiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33037 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 615 0$aPharmacology. 615 0$aCardiology. 615 0$aNeurosciences. 615 14$aPharmacology/Toxicology. 615 24$aCardiology. 615 24$aNeurosciences. 676 $a571.657 702 $aSingh$b Harpreet$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSheu$b Shey-Shing$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910253941903321 996 $aPharmacology of mitochondria$91766349 997 $aUNINA