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010   $a3-319-63953-6
024 7 $a10.1007/978-3-319-63953-6
035   $a(CKB)3710000001631550
035   $a(MiAaPQ)EBC4978945
035   $a(DE-He213)978-3-319-63953-6
035   $a(PPN)203850955
035   $a(EXLCZ)993710000001631550
100   $a20170816d2017      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $2rdacontent
182   $2rdamedia
183   $2rdacarrier
200 10$aBiomedical Applications of Acridines  $eDerivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases /$fby Jan Je?ek, Jan Hlavá?ek, Jaroslav ?ebestík
205   $a1st ed. 2017.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017.
215   $a1 online resource (237 pages) $cillustrations (some color)
225 1 $aProgress in Drug Research,$x0071-786X ;$v72
311 08$a3-319-63952-8 
320   $aIncludes bibliographical references at the end of each chapters and index.
327   $aPreliminary ToC 1 Introduction -- 2 Nomenclature -- 3. Syntheses -- 4. Interactions of acridines with nucleic acids -- 5. Intercations with proteins -- 6. Applications for treament of neurodegenerative diseases -- 7. Some applications of selective toxicities of acridines -- 8. Acridine on dendrimeric carriers -- 9 Acridines used for staining -- 10 Miscellaneous -- 11 Conclusions and outlook.
330   $aThis book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer?s disease, Parkinson?s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can  be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.
410  0$aProgress in Drug Research,$x0071-786X ;$v72
606   $aPharmaceutical chemistry
606   $aNeurochemistry
606   $aPharmacology
606   $aProteins
606   $aBioorganic chemistry
606   $aNucleic acids
606   $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000
606   $aNeurochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/B18010
606   $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007
606   $aProtein-Ligand Interactions$3https://scigraph.springernature.com/ontologies/product-market-codes/L14060
606   $aBioorganic Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C19010
606   $aNucleic Acid Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/L14011
615  0$aPharmaceutical chemistry.
615  0$aNeurochemistry.
615  0$aPharmacology.
615  0$aProteins.
615  0$aBioorganic chemistry.
615  0$aNucleic acids.
615 14$aMedicinal Chemistry.
615 24$aNeurochemistry.
615 24$aPharmacology/Toxicology.
615 24$aProtein-Ligand Interactions.
615 24$aBioorganic Chemistry.
615 24$aNucleic Acid Chemistry.
676   $a547.593
700   $aJez?ek$b Jan$4aut$4http://id.loc.gov/vocabulary/relators/aut$00
702   $aHlavá?ek$b Jan$4aut$4http://id.loc.gov/vocabulary/relators/aut
702   $aS?ebesti?k$b Jaroslav$4aut$4http://id.loc.gov/vocabulary/relators/aut
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910253940703321
996   $aBiomedical Applications of Acridines$91954756
997   $aUNINA