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010   $a3-319-60174-1
024 7 $a10.1007/978-3-319-60174-8
035   $a(CKB)3710000001631536
035   $a(DE-He213)978-3-319-60174-8
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035   $a(PPN)203851242
035   $a(EXLCZ)993710000001631536
100   $a20170831d2017      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aG-Protein-Coupled Receptor Dimers /$fedited by Katharine Herrick-Davis, Graeme Milligan, Giuseppe Di Giovanni
205   $a1st ed. 2017.
210  1$aCham :$cSpringer International Publishing :$cImprint: Humana,$d2017.
215   $a1 online resource (XVII, 501 p. 70 illus., 58 illus. in color.) 
225 1 $aThe Receptors,$x1048-6909 ;$v33
311   $a3-319-60172-5 
327   $aPart I. Introduction -- 1. From Monomers to Dimers and Beyond: An Exciting Journey in the World of the G protein-coupled Receptor Family.- 2. The use of Spatial Intensity Distribution Analysis to Examine G protein-coupled Receptor Oligomerization -- 3. Advanced Microscopy Techniques for Studying G protein-coupled Receptors.- Part II. Receptors.- 4. Light Sensing G protein-coupled Receptor Rhodopsin Dimer -- 5. Extreme Vetting of Dopamine Receptor Oligomerization -- 6. Serotonin receptors.- 7. Cannabinoid and Opioid Receptor Heteromers -- 8. Di/oligomerization of Glycoprotein Hormone Receptors.- 9. Chemokine Receptor Oligomerization to Tweak Chemotactic Responses -- 10. Secretin Receptor Dimerization. Prototypic of Class B GPCR Behavior.- 11. Receptors and RAMPs -- 12. Obligatory Heterodimerization of GABAB Receptor.- 13. Metabotropic Glutamate Receptors. Part III. Assembly and Trafficking.- 14. The monomer/homodimer Equilibrium of G protein-coupled Receptors: Formation in the Secretory Pathway and Potential Functional Significance.- 15. Probing Self-assembly of G protein-coupled Receptor Oligomers in Membranes using Molecular Dynamics Modeling and Experimental Approaches.- 16. Interaction of Membrane Cholesterol with GPCRs: Implications in Receptor Oligomerization.- Part IV. Physiology and Therapeutic Potential.- 17. Allosterism within GPCR Oligomers: Back to Symmetry.- 18. Understanding the Physiological Significance of GPCR Dimers and Oligomers -- 19. Heteromers form Novel Signaling Complexes -- 20. Heteroreceptor Complexes Implicated in Parkinson?s Disease.
330   $aG-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors. The proposed book will provide a comprehensive overview of GPCR dimers, starting with a historical perspective and including, basic information about the different dimers, how they synthesize, their signaling properties, and the many diverse physiological processes in which they are involved.  In addition to presenting information about healthy GPCR dimer activity, the book will also include a section on their pathology and therapeutic potentials.
410  0$aThe Receptors,$x1048-6909 ;$v33
606   $aNeurosciences
606   $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006
615  0$aNeurosciences.
615 14$aNeurosciences.
676   $a612.8
702   $aHerrick-Davis$b Katharine$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aMilligan$b Graeme$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aDi Giovanni$b Giuseppe$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910253940503321
996   $aG-Protein-Coupled Receptor Dimers$92065513
997   $aUNINA