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010   $a3-319-60907-6
024 7 $a10.1007/978-3-319-60907-2
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035   $a(DE-He213)978-3-319-60907-2
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100   $a20170804d2017      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $2rdacontent
182   $2rdamedia
183   $2rdacarrier
200 10$aExtracellular Matrix in Tumor Biology /$fedited by Rolf A. Brekken, Dwayne Stupack
205   $a1st ed. 2017.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017.
215   $a1 online resource (115 pages)
225 1 $aBiology of Extracellular Matrix,$x0887-3224
311   $a3-319-60906-8 
320   $aIncludes bibliographical references at the end of each chapters.
327   $a1. The extracellular matrix of tumors: a focus on fibronectin and fibulin-5 -- 2. Internalization of collagen: an important matrix turnover pathway in cancer -- 3. Lumican, a Small Leucine-Rich Proteoglycan, and Its Biological Function in Tumor Progression  -- 4. Versican: Role in Cancer Tumorigenesis -- 5. Engineering advanced models of the glioblastoma microenvironment using biomaterials -- 6. Breaching and opening basement membrane barriers: the anchor cell leads the way.
330   $aThis volume provides an overview on the influence of Extracellular Matrix (ECM) on tumor progression. It covers topics such as signaling induced by structural ECM proteins including collagen and fibronectin, the control of ECM deposition and the turnover in tumors. Also discussed are the migration of cells through basement membranes and the function of proteoglycans including lumican and veriscan in tumor progression. Biomaterial-based in-vitro models as well as C. elegans models of the tumor microenvironment are used to show how these models can lead to a greater understanding of the disease mechanisms that promote cancer progression. The book addresses researchers working on cancer biology or ECM, and oncologists alike.
410  0$aBiology of Extracellular Matrix,$x0887-3224
606   $aCancer$xResearch
606   $aImmunology
606   $aMolecular biology
606   $aOncology
606   $aProteins
606   $aCytology
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
606   $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000
606   $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X
606   $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160
606   $aReceptors$3https://scigraph.springernature.com/ontologies/product-market-codes/L14110
606   $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008
615  0$aCancer$xResearch.
615  0$aImmunology.
615  0$aMolecular biology.
615  0$aOncology.
615  0$aProteins.
615  0$aCytology.
615 14$aCancer Research.
615 24$aImmunology.
615 24$aMolecular Medicine.
615 24$aOncology.
615 24$aReceptors.
615 24$aCell Biology.
676   $a611.0182
702   $aBrekken$b Rolf A$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aStupack$b Dwayne$4edt$4http://id.loc.gov/vocabulary/relators/edt
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910253940203321
996   $aExtracellular Matrix in Tumor Biology$92056937
997   $aUNINA