LEADER 04352nam 22006015 450 001 9910253938603321 005 20200630024258.0 010 $a94-024-1170-4 024 7 $a10.1007/978-94-024-1170-6 035 $a(CKB)4100000000587470 035 $a(DE-He213)978-94-024-1170-6 035 $a(MiAaPQ)EBC5024030 035 $a(PPN)204530814 035 $a(EXLCZ)994100000000587470 100 $a20170905d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aImmune Metabolism in Health and Tumor /$fedited by Bin Li, Fan Pan 205 $a1st ed. 2017. 210 1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2017. 215 $a1 online resource (V, 223 p. 24 illus., 23 illus. in color.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1011 311 $a94-024-1168-2 320 $aIncludes bibliographical references. 327 $aMetabolism in Immune Cell Differentiation and Function -- Metabolic Regulation of T cell Immunity -- Transcriptional regulation of T cell metabolism reprograming -- Adipose tissue-resident regulatory T cells -- Immune cell metabolism in tumor microenvironment -- Regulation of Metabolism across Different Subsets of T Cells in Cancer -- Immunometabolism in Tumour Microenvironment . 330 $aThis book offers a broad overview of the concepts and research findings in immunometabolism. The immune system is made up of numerous different cell types, pathways, and components that must be able to respond rapidly to a pathogen or cancer, but must also remain quiescent in the absence of challenges. Immune cells rely on metabolic pathways to adapt to changing environments and stimuli. Additionally, these cells can be modified in function or fate by fluctuations in available nutrients. The chapters in this book describe ways in which immune cells utilize and are regulated by metabolic pathways. Topics include how immune-cell metabolism shapes immune homeostasis, and how dysregulation of these pathways can lead to immune disorders. In different contexts, such as a tumor microenvironment, immune-cell function and identity may be modified not only by cytokines and checkpoint molecules, but also by nutrient availability and other metabolic stimuli. Transcriptional reprogramming confers many of the changes in immune cell metabolism that are seen when a T-cell, for example, undergoes activation or functional adaptation to different environments. Lastly, immune cells can destructively or protectively participate in human metabolic homeostasis or disorders. This book summarizes immune-metabolism from a variety of different perspectives, including the ways in which metabolic cues, pathways, and requirements of immune cells change in conditions of homeostasis and activation. The exploration of the significance of metabolic checkpoints and other cues, particularly in the context of cancer and immune disorders, may form the foundation for the development of therapeutics. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1011 606 $aImmunology 606 $aPosttranslational modification 606 $aMedical microbiology 606 $aCancer research 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aPosttranslational Modification$3https://scigraph.springernature.com/ontologies/product-market-codes/L14090 606 $aMedical Microbiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B16003 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 615 0$aImmunology. 615 0$aPosttranslational modification. 615 0$aMedical microbiology. 615 0$aCancer research. 615 14$aImmunology. 615 24$aPosttranslational Modification. 615 24$aMedical Microbiology. 615 24$aCancer Research. 676 $a616.079 702 $aLi$b Bin$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aPan$b Fan$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910253938603321 996 $aImmune Metabolism in Health and Tumor$91993978 997 $aUNINA