LEADER 04714nam 22005415 450 001 9910253937403321 005 20200725165247.0 010 $a3-319-55769-6 024 7 $a10.1007/978-3-319-55769-4 035 $a(CKB)3710000001631519 035 $a(MiAaPQ)EBC4981693 035 $a(DE-He213)978-3-319-55769-4 035 $a(PPN)203851641 035 $a(EXLCZ)993710000001631519 100 $a20170821d2017 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aGlial Amino Acid Transporters /$fedited by Arturo Ortega, Arne Schousboe 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (341 pages) $cillustrations (some color), tables 225 1 $aAdvances in Neurobiology,$x2190-5215 ;$v16 311 $a3-319-55767-X 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aManganese and glutamate transporters gene expression,- Glycine transportes in glia cells: structural studies.- Taurine homeostasis and volume control.- Glycine transporters and its coupling with NMDA receptors.- Revised Ion/Substrate Coupling Stoichiometry of GABA Transporters.- EAAT2 and the molecular signature of amyotrophic lateral sclerosis.- Glial GABA transporters as modulators of inhibitory signalling in epilepsy and stroke.- Glial Glutamine transporters: Beyond the glutamate/glutamine shuttle.- Glutamate transporters as signaling molecules.- Regulation of the glutamate transporters expression in glia cells.- Glutamate Transport System as a Novel Therapeutic Target in Chronic Pain: Molecular Mechanisms and Pharmacology.- Monocarboxylate transporters.- Glutamate transporters role in neurological diseases -- Astrocytic GABA-transporters:Pharmacological properties and targets for antiepileptic drugs -- Glutamate transporters in the blood-brain barrier -- Development of non-GAT1 selective inhibitors; challenges and achievements. . 330 $aOur current knowledge of the role of macroglia in the physiology of the nervous system has been shaped on by both the established role of oligodendrocytes and Schwann cells in the propagation of the action potential and by the concept of the tripartite synapse. In both cases, integral membrane proteins such as receptors and transporters are crucial for the proper function of these cells. This book is an extensive review of the contribution of glial membrane transporters.  Model transporters are analysed in terms of their structure, distribution and involvement in major functions and/or pathologies of the nervous system. It is important to note that a particular emphasis has been placed in the rather unexplored signalling properties of glial transporters. Likewise, strategies toward the design of novel compounds that target membrane transporters are discussed. Different points of view of the involvement and contribution of glial transporters are presented in this volume, and the contrast of these interpretations invites the readers to broaden their interest of membrane transporters beyond the chapters of this book. No intention was made to provide a certain order to the chapters of the book; in fact any of them can be read independently. We want to express our appreciation to the contributors for their enthusiasm in the preparation of their excellent chapters that will certainly provide a fresh perspective of the exponential accumulation of knowledge that has been published in the last few years and unequivocally changing the concept of glial physiology. It is our hope that this book provides a major input to the fascinating field of membrane transporters as fundamental proteins for the establishment of a better understanding of glia-neuron interactions.  . 410 0$aAdvances in Neurobiology,$x2190-5215 ;$v16 606 $aNeurosciences 606 $aNeurobiology 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aNeurobiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L25066 615 0$aNeurosciences. 615 0$aNeurobiology. 615 14$aNeurosciences. 615 24$aNeurobiology. 676 $a599.0142 702 $aOrtega$b Arturo$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSchousboe$b Arne$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910253937403321 996 $aGlial Amino Acid Transporters$92065510 997 $aUNINA