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010   $a981-10-5987-X
024 7 $a10.1007/978-981-10-5987-2
035   $a(CKB)4100000000587485
035   $a(DE-He213)978-981-10-5987-2
035   $a(MiAaPQ)EBC5049868
035   $a(PPN)204530830
035   $a(EXLCZ)994100000000587485
100   $a20170918d2017      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aRegulation of Inflammatory Signaling in Health and Disease /$fedited by Dakang Xu
205   $a1st ed. 2017.
210  1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2017.
215   $a1 online resource (XII, 244 p. 19 illus., 18 illus. in color.) 
225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1024
311   $a981-10-5986-1 
320   $aIncludes bibliographical references.
330   $aThis book discusses recent research in innate immunity, which has revealed a large number of receptors that sense the presence of microorganisms or cellular damage in tissues. In complex tissues, many of these sensing events occur simultaneously. Thus, the downstream signaling pathways need to be integrated so that an appropriate cellular inflammatory response can be initiated. In addition, the inflammasome defines the molecular and cellular processes of inflammation in response to microbial infection. Previous data suggested that regulation of inflammasomes is mediated by microbes, but inflammasomes also have antimicrobial functions. Increasing evidence in mouse models, together with human data, strongly implicates an involvement of the inflammasome and uncontrolled inflammation in the initiation and progression of diseases with a high impact on public health.  The book reviews novel aspects of functional genomics, epigenomics, transcriptomics, post-translat ional modifications, microbiome and immunometabolism in order to understand inflammatory signaling and responses, covering recent findings on the mechanisms underlying the regulation of inflammatory responses to pathogens, dysregulation of these responses in inflammatory disease, and the use of such mechanisms to boost or subdue the inflammatory response. Bridging the gaps in understanding between the fields of human and mouse immunology, it provides valuable insights into inflammatory-mediated disease and immune defense. Such innovative perspectives in both basic and clinical research promote the translation of knowledge to the clinic.
410  0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1024
606   $aImmunology
606   $aCell biology
606   $aPosttranslational modification
606   $aMolecular biology
606   $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000
606   $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008
606   $aPosttranslational Modification$3https://scigraph.springernature.com/ontologies/product-market-codes/L14090
606   $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X
615  0$aImmunology.
615  0$aCell biology.
615  0$aPosttranslational modification.
615  0$aMolecular biology.
615 14$aImmunology.
615 24$aCell Biology.
615 24$aPosttranslational Modification.
615 24$aMolecular Medicine.
676   $a616.079
702   $aXu$b Dakang$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910253937003321
996   $aRegulation of Inflammatory Signaling in Health and Disease$91954752
997   $aUNINA