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010   $a3-319-67591-5
024 7 $a10.1007/978-3-319-67591-6
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035   $a(DE-He213)978-3-319-67591-6
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100   $a20171117d2017      u|             0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
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200 10$aTCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease$b[electronic resource] /$fedited by Adam Telerman, Robert Amson
205   $a1st ed. 2017.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017.
215   $a1 online resource (X, 309 p. 51 illus., 36 illus. in color.) 
225 1 $aResults and Problems in Cell Differentiation,$x0080-1844 ;$v64
311   $a3-319-67590-7 
320   $aIncludes bibliographical references at the end of each chapters.
327   $a1 Introduction: How we encountered TCTP and our purpose in studying it -- 2 Structural insights into TCTP and its interactions with ligands and proteins -- 3 Structure-Function relationship of TCTP -- 4 The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation -- 5 Current understanding of the TCTP interactome -- 6 Role and fate of TCTP in protein degradative pathways -- 7 Roles of the Translationally Controlled Tumor Protein (TCTP) in plant development -- 8 Function of Translationally controlled tumor protein in organ growth: Lessons from Drosophila studies -- 9 Translationally controlled tumor protein (TCTP/HRF) present in animal venoms -- 10 Tctp in Neuronal Circuitry Assembly -- 11 Elusive role of TCTP protein and mRNA in cell cycle and cytoskeleton regulation -- 12 TCTP protein and the cellular response to ionizing radiation-induced DNA damage -- 13 TCTP has a crucial role in the different stages of Prostate Cancer malignant progression -- 14 Role of TCTP for cellular differentiation and cancer therapy -- 15 Targeting TCTP with sertraline and thioridazine in cancer treatment -- 16 . History of Histamine Releasing Factor (HRF)/TCTP including a Potential Therapeutic Target in Asthma and Allergy.
330   $aThis book highlights the role of the Translationally Controlled Tumor Protein (TCTP) in cell signaling, cell fate and the resulting connection to disease development. It begins by discussing the structure/function of TCTP, before exploring its role in different species ranging from plants to Drosophila and covering fields such as development, the cytoskeleton, cell division, DNA fragility and apoptosis. In turn, the book?s final section is devoted to the role of TCTP in disease, namely asthma and diverse cancers, and ultimately as a target for the treatment of malignancies. What is the common denominator between all these processes and why is TCTP necessary in order for them to occur, even in the worst case such as cancer? The book seeks to provide meaningful answers to this and other key questions. Presenting a broad and revealing view on the topic, it offers an informative guide for scientists and students alike.
410  0$aResults and Problems in Cell Differentiation,$x0080-1844 ;$v64
606   $aCancer research
606   $aProteins 
606   $aStem cells
606   $aCell cycle
606   $aApoptosis
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
606   $aProtein Structure$3https://scigraph.springernature.com/ontologies/product-market-codes/L14050
606   $aStem Cells$3https://scigraph.springernature.com/ontologies/product-market-codes/L16010
606   $aCell Cycle Analysis$3https://scigraph.springernature.com/ontologies/product-market-codes/L16030
606   $aApoptosis$3https://scigraph.springernature.com/ontologies/product-market-codes/L16060
615  0$aCancer research.
615  0$aProteins .
615  0$aStem cells.
615  0$aCell cycle.
615  0$aApoptosis.
615 14$aCancer Research.
615 24$aProtein Structure.
615 24$aStem Cells.
615 24$aCell Cycle Analysis.
615 24$aApoptosis.
676   $a614.5999
702   $aTelerman$b Adam$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aAmson$b Robert$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910253933603321
996   $aTCTP$91954748
997   $aUNINA