LEADER 04827nam 22006975 450 001 9910253924303321 005 20220218101036.0 010 $a3-319-54064-5 024 7 $a10.1007/978-3-319-54064-1 035 $a(CKB)4340000000061972 035 $a(DE-He213)978-3-319-54064-1 035 $a(MiAaPQ)EBC6314111 035 $a(MiAaPQ)EBC5588788 035 $a(Au-PeEL)EBL5588788 035 $a(OCoLC)989877100 035 $a(PPN)202993450 035 $a(EXLCZ)994340000000061972 100 $a20170602d2017 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aPhylogenomics$b[electronic resource] $eAn Introduction /$fby Christoph Bleidorn 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (XIII, 222 p. 89 illus., 87 illus. in color.) 311 $a3-319-54062-9 327 $a1. Genomes -- 01.1 Prokaryotes vs. Eukaryotes -- 01.2 Genome Structure -- 01.3 Genome Sizes -- 01.4 Human Genome and Ancient DNA (Neandertaler, Denisova) -- 2. Genomes of Organelles -- 02.1 Mitochondria -- 02.2 Plastids -- 02.3 Outlook Obligate Endosymbionts -- 3. Transcriptomes -- 03.1 mRNA -- 03.2 Transcripts -- 03.3 Expression Level -- 03.4 Alternative Splicing -- 4. Sequencing Techniques -- 04.1 Sanger -- 04.2 Illumina -- 04.3 454 -- 04.4 PacBio -- 04.5 Outlook Nanopore Sequencing -- 5. Genome Sequencing Strategies -- 05.1 Whole Genome Shotgun -- 05.2 RADseq -- 05.3 Target Enrichment -- 05.4 RNAseq -- 6. Assembly and Mapping -- 06.1 Assembling Strategies (kmer vs OLC) -- 06.2 Data Quality and Filtering -- 06.3 Re-Sequencing and Mapping -- 06.4 De novo Assembly Genome -- 06.5 De novo Assembly Transcriptome -- 7. Locating Genes -- 07.1 Orthology vs. Paralogy -- 07.2 BLAST and Successors -- 07.3 Hidden Markov Profile -- 07.4 Ortholog Conjecture -- 8. Alignment -- 08.1 Alignment Strategies -- 08.2 Alignment Masking -- 9. Phylogenetic Analysis -- 09.1 Distance Measurements -- 09.2 Maximum Parsimony -- 09.3 Maximum Likelihood -- 09.4 Bayesian Inference -- 09.5 Supermatrix vs. Single Gene Analysis (Gene Trees vs. Species Trees) -- 10. Systematic Errors in phylogenetic Analysis -- 10.1 Prediction: Evolutionary Models -- 10.2 Heterogenity Nucleotide/Amino Acid-Composition -- 10.3 Variation of substitution rate between the lines -- 10.4 Variation of substitution rate over time -- 10.5 New Approaches to Correct systematic Errors -- 11. Genome-wide Characteristics -- 11.1 Gene Order -- 11.2 Mobile Elements -- 11.3 microRNAs -- 11.4 Differences in the genetic code -- 12. Index -- 13. References. 330 $aThis unique textbook provides a clear and concise overview of the key principles of the complex field of phylogenomics, with a particular focus on sequencing technologies that are crucial to studying and understanding interrelations in evolutionary genomics. It includes chapters dedicated to the analysis of nucleotide sequences using assembling and alignment methods and also discusses the main strategies for phylogenetic studies, systematic errors and their correction. This highly readable textbook is intended for graduate students and young researchers with an interest in phylogenetics and evolutionary developmental biology. 606 $aEvolutionary biology 606 $aHuman genetics 606 $aBioinformatics 606 $aMicrobial genetics 606 $aMicrobial genomics 606 $aAnimal genetics 606 $aEvolutionary Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L21001 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aBioinformatics$3https://scigraph.springernature.com/ontologies/product-market-codes/L15001 606 $aMicrobial Genetics and Genomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L32010 606 $aAnimal Genetics and Genomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L32030 615 0$aEvolutionary biology. 615 0$aHuman genetics. 615 0$aBioinformatics. 615 0$aMicrobial genetics. 615 0$aMicrobial genomics. 615 0$aAnimal genetics. 615 14$aEvolutionary Biology. 615 24$aHuman Genetics. 615 24$aBioinformatics. 615 24$aMicrobial Genetics and Genomics. 615 24$aAnimal Genetics and Genomics. 676 $a576.88 700 $aBleidorn$b Christoph$4aut$4http://id.loc.gov/vocabulary/relators/aut$0980209 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910253924303321 996 $aPhylogenomics$92235894 997 $aUNINA