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010   $a3-319-52715-0
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100   $a20170526d2017      u|         0
101 0 $aeng
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181   $ctxt$2rdacontent
182   $cc$2rdamedia
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200 14$aThe Molecular Biology of Photorhabdus Bacteria /$fedited by Richard H. ffrench-Constant
205   $a1st ed. 2017.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017.
215   $a1 online resource (X, 213 p.) 
225 1 $aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v402
311   $a3-319-52714-2 
320   $aIncludes bibliographical references at the end of each chapters.
327   $aInsecticidal Toxin complexes from Photorhabdus luminescens -- Identifying anti-host effectors in Photorhabdus -- Flagellar regulation and virulence in the entomopathogenic bacteria Xenorhabdus nematophila and Photorhabdus luminescens -- Natural products from Photorhabdus and other entomopathogenic bacteria -- The regulation of secondary metabolism in Photorhabdus -- Quorum sensing and LuxR solos in Photorhabdus -- Insect immunity to entomopathogenic nematodes and their mutualistic bacteria -- Photorhabdus asymbiotica as an insect and human pathogen -- A review of clinical cases of infection with Photorhabdus asymbiotica -- A Practical Guide to Recombineering in Photorhabdus and Xenorhabdus.
330   $aThis book provides an essential update on the startling array of novel insecticidal toxins and drugs produced by the fascinating bacterium Photorhabdus. The respective chapters describe everything from the detailed molecular biology of the ?Toxin complexes? or Tc?s to the complexity of insect immune response in relation to both the bacterium and its nematode vector. The volume covers both primary (toxin production and regulation) and secondary (natural product synthesis and regulation) metabolism and emphasises the potential use of toxins and drugs in both agriculture and medicine. It also discusses in detail two totally novel quorum sensing mechanisms and the likely role of LuxR solos in sensing the presence of different bacterial hosts. Lastly, the book explores the unique case of P. asymbiotica, which seems to have evolved the ability to infect both insects and humans. This synthesis proves that Photorhabdus truly does offer a ?gold mine? for the discovery of novel insecticidal proteins and novel natural products with potential uses in agriculture and medicine alike.
410  0$aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v402
606   $aPharmacology
606   $aBacteria
606   $aMedical microbiology
606   $aAgriculture
606   $aImmunology
606   $aPharmacology
606   $aBacteria
606   $aMedical Microbiology
606   $aAgriculture
606   $aImmunology
615  0$aPharmacology.
615  0$aBacteria.
615  0$aMedical microbiology.
615  0$aAgriculture.
615  0$aImmunology.
615 14$aPharmacology.
615 24$aBacteria.
615 24$aMedical Microbiology.
615 24$aAgriculture.
615 24$aImmunology.
676   $a576.118
702   $affrench-Constant$b Richard H$4edt$4http://id.loc.gov/vocabulary/relators/edt
801  0$bMiAaPQ
801  1$bMiAaPQ
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906   $aBOOK
912   $a9910253918803321
996   $aThe Molecular Biology of Photorhabdus Bacteria$92239793
997   $aUNINA