LEADER 00798nam2-22002771i-450- 001 990008420360403321 005 20061120124650.0 035 $a000842036 035 $aFED01000842036 035 $a(Aleph)000842036FED01 035 $a000842036 100 $a20061116d1988----km-y0itay50------ba 101 0 $aita 102 $aIT 105 $aa-------001yy 200 1 $aBanche di credito ordinario e organizzazione del territorio in Italia$fRenato Mazzuca 215 $ap. 203-211$cill. 463 0$1001000746911 610 0 $aItalia$aBanche 700 1$aMazzuca,$bRenato$0249895 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aAN 912 $a990008420360403321 959 $aILFGE 996 $aBanche di credito ordinario e organizzazione del territorio in Italia$9726181 997 $aUNINA LEADER 03457nam 22005655 450 001 9910253916903321 005 20250609111403.0 010 $a3-319-57127-3 024 7 $a10.1007/978-3-319-57127-0 035 $a(CKB)3710000001406131 035 $a(DE-He213)978-3-319-57127-0 035 $a(MiAaPQ)EBC4874789 035 $a(PPN)202991334 035 $a(MiAaPQ)EBC6235500 035 $a(EXLCZ)993710000001406131 100 $a20170609d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCell Division Machinery and Disease /$fedited by Monica Gotta, Patrick Meraldi 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (XIV, 235 p. 33 illus., 32 illus. in color.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1002 311 08$a3-319-57125-7 320 $aIncludes bibliographical references and index. 327 $a1.Meiotic divisions: no place for gender equality -- 2.Consequences of centrosome dysfunction during brain development -- 3.Dividing with extra centrosomes: a double edged sword for cancer cells -- 4.Kinetochore malfunction in human pathologies -- 5.The elephant in the room: the role of microtubules in cancer -- 6.Clinical development of anti-mitotic drugs in cancer -- 7.Mitotic dysfunction associated with aging hallmarks -- 8.Unbalanced Growth, Senescence and Aging -- 9.The spindle orientation machinery beyond mitosis: when cell specialization demands polarization. 330 $aThis book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1002 606 $aCell cycle 606 $aCell physiology 606 $aCancer$xResearch 606 $aCell Cycle Analysis$3https://scigraph.springernature.com/ontologies/product-market-codes/L16030 606 $aCell Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L33010 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 615 0$aCell cycle. 615 0$aCell physiology. 615 0$aCancer$xResearch. 615 14$aCell Cycle Analysis. 615 24$aCell Physiology. 615 24$aCancer Research. 676 $a571.84 702 $aGotta$b Monica$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMeraldi$b Patrick$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910253916903321 996 $aCell Division Machinery and Disease$92065490 997 $aUNINA