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010   $a3-319-57127-3
024 7 $a10.1007/978-3-319-57127-0
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035   $a(DE-He213)978-3-319-57127-0
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035   $a(PPN)202991334
035   $a(EXLCZ)993710000001406131
100   $a20170609d2017      u|             0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aCell Division Machinery and Disease$b[electronic resource] /$fedited by Monica Gotta, Patrick Meraldi
205   $a1st ed. 2017.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017.
215   $a1 online resource (XIV, 235 p. 33 illus., 32 illus. in color.) 
225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1002
311   $a3-319-57125-7 
320   $aIncludes bibliographical references and index.
327   $a1.Meiotic divisions: no place for gender equality -- 2.Consequences of centrosome dysfunction during brain development -- 3.Dividing with extra centrosomes: a double edged sword for cancer cells -- 4.Kinetochore malfunction in human pathologies -- 5.The elephant in the room: the role of microtubules in cancer -- 6.Clinical development of anti-mitotic drugs in cancer -- 7.Mitotic dysfunction associated with aging hallmarks -- 8.Unbalanced Growth, Senescence and Aging -- 9.The spindle orientation machinery beyond mitosis: when cell specialization demands polarization.
330   $aThis book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases.
410  0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1002
606   $aCell cycle
606   $aCell physiology
606   $aCancer research
606   $aCell Cycle Analysis$3https://scigraph.springernature.com/ontologies/product-market-codes/L16030
606   $aCell Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L33010
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
615  0$aCell cycle.
615  0$aCell physiology.
615  0$aCancer research.
615 14$aCell Cycle Analysis.
615 24$aCell Physiology.
615 24$aCancer Research.
676   $a571.84
702   $aGotta$b Monica$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aMeraldi$b Patrick$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910253916903321
996   $aCell Division Machinery and Disease$92065490
997   $aUNINA