LEADER 03735nam  22005295  450 
001 9910253913603321
005 20200705115637.0
010   $a3-658-18623-2
024 7 $a10.1007/978-3-658-18623-4
035   $a(CKB)3710000001411701
035   $a(DE-He213)978-3-658-18623-4
035   $a(MiAaPQ)EBC4872972
035   $a(PPN)202989550
035   $a(EXLCZ)993710000001411701
100   $a20170606d2017      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aImpact of Survivin Acetylation on its Biological Function /$fby David Dannheisig
205   $a1st ed. 2017.
210  1$aWiesbaden :$cSpringer Fachmedien Wiesbaden :$cImprint: Springer Spektrum,$d2017.
215   $a1 online resource (XXIII, 104 p. 41 illus., 10 illus. in color.) 
225 1 $aBestMasters,$x2625-3577
311   $a3-658-18622-4 
327   $aApoptosis ? The Programmed Suicide -- Cancer ? The Enemy Inside -- Nucleocytoplasmic Transport? Cellular Navigation -- Biological Function of Survivin -- Protein modification ? Make-Up for Proteins -- Cell cycle ? Virchow?s Heritage.
330   $aIn his research, David Dannheisig investigates the influence of lysine129 acetylation on the biological function of survivin including alteration of nucleocytoplasmic shuttling as well as dimerization behavior. Since survivin participates in two major hallmarks of oncogenesis, namely cell death inhibition and chromosomal segregation during the cell cycle, it reflects a valuable target in cancer therapy and research. The author establishes proximity-dependent, fluorescence-microscopic methods to quantify the interaction of survivin with the export receptor Crm1 as well as the homodimerization itself. In the future, those systems can be used to examine the feasible effect of chemical modulators which are targeting these interactions in a cellular background. The outcome achieved is an essential step towards the enhancement of potential cancer therapies. Contents Apoptosis ? The Programmed Suicide Cancer ? The Enemy Inside Nucleocytoplasmic Transport? Cellular Navigation Biological Function of Survivin Protein modification ? Make-Up for Proteins Cell cycle ? Virchow?s Heritage Target Groups Lecturers, students and researchers in the biological-medical sector Practitioners in the fields of molecular biology, cell biology, fluorescence microscopy, medical biology, protein interaction studies The Author David Dannheisig currently is a student of the International Graduate School in Molecular Medicine (IGradU) pursuing his PhD (Dr. rer. nat) degree at the Institute of Biochemistry and Molecular Biology (iBMB) at Ulm University, Germany.
410  0$aBestMasters,$x2625-3577
606   $aCancer research
606   $aBiomedical engineering
606   $aCell biology
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
606   $aBiomedical Engineering/Biotechnology$3https://scigraph.springernature.com/ontologies/product-market-codes/B24000
606   $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008
615  0$aCancer research.
615  0$aBiomedical engineering.
615  0$aCell biology.
615 14$aCancer Research.
615 24$aBiomedical Engineering/Biotechnology.
615 24$aCell Biology.
676   $a614.5999
700   $aDannheisig$b David$4aut$4http://id.loc.gov/vocabulary/relators/aut$0937024
906   $aBOOK
912   $a9910253913603321
996   $aImpact of Survivin Acetylation on its Biological Function$92110401
997   $aUNINA