LEADER 04168nam 22006375 450 001 9910253911103321 005 20200630023349.0 010 $a9789402410570 024 7 $a10.1007/978-94-024-1057-0 035 $a(CKB)3710000001083987 035 $a(DE-He213)978-94-024-1057-0 035 $a(MiAaPQ)EBC4817784 035 $a(PPN)199764190 035 $a(EXLCZ)993710000001083987 100 $a20170303d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAquaporins /$fedited by Baoxue Yang 205 $a1st ed. 2017. 210 1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2017. 215 $a1 online resource (XII, 278 p. 69 illus., 59 illus. in color.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v969 311 $a94-024-1055-4 311 $a94-024-1057-0 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aMolecular Biology of Aquaporins -- The Evolutionary Aspects of Aquaporin Family -- Transport Characteristics of Aquaporins -- Aquaporins and Gland Secretion -- Aquaporins in Nervous System -- Aquaporins in Cardiovascular System -- Aquaporins in Respiratory System -- Aquaporins in Digestive System -- Aquaporins in Urinary System -- The physiological role and regulation of aquaporins in teleost germ cells -- Aquaporins in the Skin -- Aquaporins in Eye -- Aquaporins in Fetal Development -- Diabetes Insipidus -- Aquaporins in Obesity -- Aquaporin-targeted Therapeutics: State-of-the-field -- Water Transport Mediated by Other Membrane Proteins -- Methods to measure water permeability. 330 $aThis book provides a state-of-the-art report on our current understanding of aquaporins and the future direction of the field. Aquaporins (AQPs) are a group of water-channel proteins that are specifically permeable to water and other small molecules, such as glycerol and urea. To date thirteen water-channel proteins (AQP0 ? AQP12) have been cloned and the mechanisms and physiological functions of water transport across biological membranes have long been the subject of interest. Recent advances in the molecular biology and physiology of water transport have yielded new insights into how and why water moves across cell membranes, and studies on aquaporin knockout mouse models suggest that aquaporins are involved in the development of some diseases and they may be useful targets of research into selective-inhibitor drugs. By focusing on the advances made over the last 20 years in the biophysics, genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of aquaporins in mammalian cell membranes, this book provides novel insights into further mechanisms and the physiological significance of water and some small molecule transport in mammals in order to stimulate further research in new directions. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v969 606 $aPharmacology 606 $aProteins 606 $aHuman physiology 606 $aCell membranes 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 606 $aMembrane Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16050 615 0$aPharmacology. 615 0$aProteins. 615 0$aHuman physiology. 615 0$aCell membranes. 615 14$aPharmacology/Toxicology. 615 24$aProtein Science. 615 24$aHuman Physiology. 615 24$aMembrane Biology. 676 $a572.696 702 $aYang$b Baoxue$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910253911103321 996 $aAquaporins$93010128 997 $aUNINA