LEADER 05129nam 22006855 450 001 9910253910603321 005 20200704113043.0 010 $a3-319-58194-5 024 7 $a10.1007/978-3-319-58194-1 035 $a(CKB)3710000001388637 035 $a(DE-He213)978-3-319-58194-1 035 $a(MiAaPQ)EBC4864868 035 $a(PPN)20147199X 035 $a(EXLCZ)993710000001388637 100 $a20170522d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHistamine and Histamine Receptors in Health and Disease /$fedited by Yuichi Hattori, Roland Seifert 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (VIII, 363 p. 90 illus., 30 illus. in color.) 225 1 $aHandbook of Experimental Pharmacology,$x0171-2004 ;$v241 311 $a3-319-58192-9 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aPart 1: New Analytical tools -- Histamine and histamine receptors: State of the art -- Mass-spectrometric methods for the detection of histamine and histamine metabolites -- Fluorescent ligands and radioligands for the analysis of histamine receptors -- Molecular analysis of histamine receptors: Structural analysis of the histamine H1-receptor -- Molecular modelling approaches for the analysis of histamine receptors -- Cellular analysis of histamine receptors: Histamine release from human mast cells and basophils -- Histamine H2-receptor in blood cells: A suitable target for the treatment of acute myeloid leukemia -- Histamine H1-receptor-regulated gene expression and drug action of antihistamines -- Histamine metabolism and transport: Analysis of the role of histamine and genetically engineered mice in a human disease model -- Histamine clearance through polyspecific transporters in the brain -- Histamine decarboxylase deficiency as a cause for Tourette syndrome -- Histamine food poisoning -- Integrative role of histamine in major organ systems: Pharmacological implications: Regulation of the cardiovascular system by histamine -- Regulation of eating behavior by histamine -- Role of the histamine H3-receptor in the CNS -- Role of the histamine H4-receptor in bronchial asthma -- The histamine H4-receptor in pruritic skin disease -- Histamine in allergy and antihistamines. 330 $aThis book provides a comprehensive overview on current histamine and histamine receptor research in context of human health and disease and reflect the multidisciplinary nature of the field. While the editors realize that it is almost impossible to cover the field completely within the constraints of a single HEP volume, nonetheless, all important aspects will be covered in one way or the other. An overarching introductory chapter will link the individual chapters and provide an overview on the field. This chapter will also link the book to the previous HEP volume on histamine receptors and the recent HEP volume on the pharmacology of itch. Great attention will be paid to complementation of existing literature while avoiding undue duplication. The book will cover new methods for analysis of histamine and histamine metabolites, development of methods for histamine receptor analysis, signal transduction, histamine release, regulation of immune cells by histamine, histamine metabolism and associated diseases, regulation of major organ systems by histamine and development of new drugs and experimental tools for the study of histamine receptors. 410 0$aHandbook of Experimental Pharmacology,$x0171-2004 ;$v241 606 $aPharmacology 606 $aBiochemistry 606 $aNeurosciences 606 $aImmunology 606 $aEndocrinology  606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aEndocrinology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33053 615 0$aPharmacology. 615 0$aBiochemistry. 615 0$aNeurosciences. 615 0$aImmunology. 615 0$aEndocrinology . 615 14$aPharmacology/Toxicology. 615 24$aBiochemistry, general. 615 24$aNeurosciences. 615 24$aImmunology. 615 24$aEndocrinology. 676 $a599.013 702 $aHattori$b Yuichi$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSeifert$b Roland$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910253910603321 996 $aHistamine and histamine receptors in health and disease$91764199 997 $aUNINA