LEADER 04406nam 22006495 450 001 9910253909003321 005 20200706205143.0 010 $a3-319-53774-1 024 7 $a10.1007/978-3-319-53774-0 035 $a(CKB)3710000001364502 035 $a(DE-He213)978-3-319-53774-0 035 $a(MiAaPQ)EBC4860805 035 $a(PPN)201473232 035 $a(EXLCZ)993710000001364502 100 $a20170516d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCellular Injury in Liver Diseases$b[electronic resource] /$fedited by Wen-Xing Ding, Xiao-Ming Yin 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (XIII, 263 p. 26 illus., 22 illus. in color.) 225 1 $aCell Death in Biology and Diseases,$x2625-2902 311 $a3-319-53773-3 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aPreface -- 1) Regulation of cell death in Hepatocytes, An overview -- 2) Cell death of cholangiocytes and its role in the development of biliary diseases -- 3) Cell death and autophagy in hepatic stellate cell activation and function -- 4) Regulation of Kupffer?s cell death, survival and activation during liver injury -- 5) Drug-induced liver injury (DILI), a general overview -- 6) Mechanisms of acetaminophen-induced liver injury -- 7) HIV-protease inhibitor-induced liver injury -- 8) Mechanisms of Lipotoxicity in Liver Injury -- 9) Cell Death in NAFLD and NASH -- 10) Cell death and autophagy in alcohol-induced liver injury -- 11) Bile acid-induced cell death, cholestasis and liver injury -- 12) Cell death in ischemia-reperfusion induced liver injury -- 13) Lectin (ConA)-induced liver injury and autoimmune hepatitis -- 14) Cell death and autophagy in viral hepatitis -- 15) Cell death and autophagy in liver tumorigenesis and liver cancer. 330 $aThis comprehensive volume describes drug and virus-mediated hepatocyte injury, alcohol, lipid and bile acid-induced hepatocyte injury in addition to ischemia-reperfusion-mediated liver injury. The chapter authors who discuss these topics are leading experts on cell death in liver diseases. The authors link these different types of liver injury to the commonly associated liver inflammation, fibrosis and tumorigenesis. Other topics explored include the various forms of cell death and cell survival pathways that have been identified in the liver, such as apoptosis, necroptosis, pryoptosis and autophagy. This book, along with its companion volume, Molecules, Systems and Signaling in Hepatic Cell Death, provides a thorough and comprehensive discussion on the topic of cell death and liver disease. Cellular Injury in Liver Diseases is an essential addition to the Cell Death in Biology and Diseases series and will appeal to scientists, clinicians and those doing research for drug discovery. . 410 0$aCell Death in Biology and Diseases,$x2625-2902 606 $aCell cycle 606 $aApoptosis 606 $aCell physiology 606 $aHepatology 606 $aCell membranes  606 $aCell Cycle Analysis$3https://scigraph.springernature.com/ontologies/product-market-codes/L16030 606 $aApoptosis$3https://scigraph.springernature.com/ontologies/product-market-codes/L16060 606 $aCell Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L33010 606 $aHepatology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33088 606 $aMembrane Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16050 615 0$aCell cycle. 615 0$aApoptosis. 615 0$aCell physiology. 615 0$aHepatology. 615 0$aCell membranes . 615 14$aCell Cycle Analysis. 615 24$aApoptosis. 615 24$aCell Physiology. 615 24$aHepatology. 615 24$aMembrane Biology. 676 $a571.84 702 $aDing$b Wen-Xing$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aYin$b Xiao-Ming$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910253909003321 996 $aCellular Injury in Liver Diseases$92233501 997 $aUNINA