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010   $a981-10-4810-X
024 7 $a10.1007/978-981-10-4810-4
035   $a(CKB)3710000001406279
035   $a(DE-He213)978-981-10-4810-4
035   $a(MiAaPQ)EBC4877884
035   $a(PPN)202989283
035   $a(EXLCZ)993710000001406279
100   $a20170614d2017      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aBiology of Vascular Smooth Muscle: Vasoconstriction and Dilatation /$fby Yuansheng Gao
205   $a1st ed. 2017.
210  1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2017.
215   $a1 online resource (XIII, 286 p. 43 illus., 33 illus. in color.) 
311   $a981-10-4809-6 
320   $aIncludes bibliographical references at the end of each chapters.
327   $aArchitecture of the vessel wall -- Ultrastructure of vascular smooth muscle -- Vascular endothelium -- Electrical and mechanical properties of vascular smooth muscle -- Biochemistry of the contractile proteins of smooth muscle -- Metabolism of vascular smooth muscle -- Neurotransmitters -- Endothelium-derived factors -- Local metabolic factors -- Shear stress myogenic response and blood flow autoregulation -- Intracellular Ca2+ regulation -- Regulation of myosin light chain phosphorylation -- Cyclic AMP signalling -- Cyclic GMP signaling -- Coronary vasoreactivity -- Cerebral vasoreactivity -- Pulmonary vasoreactivity -- Hypoxic vasoreactivity -- Ageing and vasoreactivity.
330   $aThis book provides a concise yet comprehensive review of the morphological, biochemical, electrical, mechanical, and metabolic properties of vascular smooth muscle, the regulation of vascular activities and the intracellular signaling involved. It particularly focuses on recently identified vasoactive agents, enzymes and transduction mechanisms. It also discusses the latest findings in the regulation of cerebral, coronary and pulmonary circulation as well as vascular activity under hypoxia and ageing. The contraction and dilatation activities of vasculature are of fundamental importance for maintaining circulation homeostasis and adapting physiological changes. Over the last four decades, there have been significant advances in our understanding of the biochemical, structural, genetic, physiological, and pharmacological aspects of vascular activity regulation, and these insights into the responsiveness of blood vessels under normal and pathophysiological conditions help to provide valuable weapons in the fight vascular diseases. The book is of interest to researchers and graduate students, both in basic research and in clinic settings, in the field of vascular biology.
606   $aHuman physiology
606   $aCell physiology
606   $aAngiology
606   $aMolecular biology
606   $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004
606   $aCell Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L33010
606   $aAngiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33010
606   $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X
615  0$aHuman physiology.
615  0$aCell physiology.
615  0$aAngiology.
615  0$aMolecular biology.
615 14$aHuman Physiology.
615 24$aCell Physiology.
615 24$aAngiology.
615 24$aMolecular Medicine.
676   $a612
700   $aGao$b Yuansheng$4aut$4http://id.loc.gov/vocabulary/relators/aut$0989761
906   $aBOOK
912   $a9910253908703321
996   $aBiology of Vascular Smooth Muscle$92996350
997   $aUNINA