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010   $a981-10-4310-8
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100   $a20170621d2017      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
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200 10$aRNA Activation /$fedited by Long-Cheng Li
205   $a1st ed. 2017.
210  1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2017.
215   $a1 online resource (XIV, 239 p. 45 illus., 38 illus. in color.) 
225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v983
311   $a981-10-4309-4 
320   $aIncludes bibliographical references at the end of each chapters and index.
327   $aPART I Exogenous RNAa -- PART II Endogenous RNAa -- PART III RNA activation guided by other small RNAs -- PART IV Developing RNAa-based therapeutics -- .
330   $aThis book offers an essential guide to RNA activation (RNAa), an emerging and fascinating new field. RNAa is a small RNA-guided and Argonaute-dependent gene regulation phenomenon in which promoter-targeted short double-stranded RNAs (dsRNAs) induce target gene expression at the transcriptional level. It occurs primarily in the nucleus and can be mediated by artificially designed short duplex RNAs that target regulatory sequences (e.g., promoters, genes? 3? termini and enhancers) and naturally occurring small RNAs (e.g., miRNAs and C. elegans 22G-RNAs). With contributions from internationally respected RNA experts, this book provides comprehensive coverage of different RNAa mechanisms and a timely update on recent advances in RNAa research, with a focus on developing RNAa-based therapeutics. Special chapters are also devoted to the topics of gene activation induced by antisense oligonucleotides and the CRISPR system. As the first book to cover RNAa, it will be of interest to a wide audience, from scientists in academia and the pharmaceutical industry to clinicians who wish to further explore the biology of RNAa and related phenomena, so as to harness their full potential for use in biotechnology and drug development. .
410  0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v983
606   $aGene expression
606   $aBiochemistry
606   $aCytology
606   $aMolecular biology
606   $aCancer$xResearch
606   $aGene Expression$3https://scigraph.springernature.com/ontologies/product-market-codes/B12010
606   $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005
606   $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008
606   $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
615  0$aGene expression.
615  0$aBiochemistry.
615  0$aCytology.
615  0$aMolecular biology.
615  0$aCancer$xResearch.
615 14$aGene Expression.
615 24$aBiochemistry, general.
615 24$aCell Biology.
615 24$aMolecular Medicine.
615 24$aCancer Research.
676   $a572.88
702   $aLi$b Long-Cheng$4edt$4http://id.loc.gov/vocabulary/relators/edt
801  0$bMiAaPQ
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906   $aBOOK
912   $a9910253908003321
996   $aRNA Activation$91993951
997   $aUNINA