LEADER 05840nam 22005775 450 001 9910253905203321 005 20200629163726.0 010 $a1-4939-6383-X 024 7 $a10.1007/978-1-4939-6383-6 035 $a(CKB)3710000000829390 035 $a(DE-He213)978-1-4939-6383-6 035 $a(MiAaPQ)EBC4644564 035 $a(PPN)194802213 035 $a(EXLCZ)993710000000829390 100 $a20160813d2016 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDiscoidin Domain Receptors in Health and Disease /$fedited by Rafael Fridman, Paul H. Huang 205 $a1st ed. 2016. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2016. 215 $a1 online resource (XIV, 355 p. 82 illus., 55 illus. in color.) 311 $a1-4939-6381-3 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aPart I: Discoidin Domain Receptor biology and roles in physiology -- DDRs: Binding properties, cell adhesion and modulation of integrin function -- DDRs and collagen fibrillogenesis -- DDR Structural Biology -- DDR Mouse models -- DDR in Invertebrates -- Part II: Discoidin Domain Receptors in Cancer -- Discoidin Domain Receptors and Disease -- Discoidin Domain Receptors in Normal Mammary Development and Breast Cancer Progression -- Discoidin Domain Receptors in Lung Cancer -- DDRs in healthy and cancerous reproductive systems -- Small Molecule Inhibitors of Discoidin Domain Receptors -- Discoidin Domain Receptor Signaling Networks -- Discoidin Domain Receptor Signaling and Pharmacological Inhibitors -- Functions of DDR1 in epithelial cell differentiation -- Part III: Discoidin Domain Receptors in other pathologies -- Discoidin Domain Receptor 2 in Development of Osteoarthritis -- DDR1 in Renal Function and Disease -- Discoidin Domain Receptors in Liver Fibrosis -- The role of DDRs in Atherosclerosis -- Discoidin Domain Receptors in Cardiac Development. 330 $aThe interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting on collagen sensors; transducing signals that regulate cell polarity, tissue morphogenesis, cell differentiation, and collagen deposition. DDRs play a key role in diseases that are characterized by dysfunction of the stromal component, which lead to abnormal collagen deposition and the resulting fibrotic response that disrupt normal organ function in disease of the cardiovascular system, lungs and kidneys, just to mention a few. In cancer, DDRs are hijacked by tumor and stromal cells to disrupt normal cell-collagen communication and initiate pro-oncogenic programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function, and contribute to cancer progression. Therefore, the strong causative association between altered RTK function and disease it is been translated today in the development of specific tyrosine kinase inhibitors targeting DDRs for various disease conditions. In spite of the accumulating evidence highlighting the importance of DDRs in health and diseases, there is still much to learn about these unique RTKs, as of today there is a lack in the medical literature of a book dedicated solely to DDRs. This is the first comprehensive volume dedicated to DDRs, which will fill a gap in the field and serve those interested in the scientific community to learn more about these important receptors in health and disease. 606 $aCancer research 606 $aMedical microbiology 606 $aMedical biochemistry 606 $aCell biology 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aMedical Microbiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B16003 606 $aMedical Biochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/H35005 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 615 0$aCancer research. 615 0$aMedical microbiology. 615 0$aMedical biochemistry. 615 0$aCell biology. 615 14$aCancer Research. 615 24$aMedical Microbiology. 615 24$aMedical Biochemistry. 615 24$aCell Biology. 676 $a614.5999 702 $aFridman$b Rafael$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aHuang$b Paul H$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910253905203321 996 $aDiscoidin Domain Receptors in Health and Disease$92527128 997 $aUNINA