LEADER 04359nam 22006255 450 001 9910253895503321 005 20200629132732.0 010 $a3-319-42316-9 024 7 $a10.1007/978-3-319-42316-6 035 $a(CKB)3710000000873121 035 $a(DE-He213)978-3-319-42316-6 035 $a(MiAaPQ)EBC4700002 035 $a(PPN)195507703 035 $a(EXLCZ)993710000000873121 100 $a20160929d2016 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aProteogenomics /$fedited by Ákos Végvári 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (VIII, 184 p. 57 illus., 55 illus. in color.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v926 311 $a3-319-42314-2 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aProteogenomic Tools and Approaches to Explore Protein Coding Landscapes of Eukaryotic Genomes -- Next Generation Sequencing Data and Proteogenomics -- Proteogenomics: Key Driver for Clinical Discovery and Personalized Medicine -- Identification of Small Novel Coding Sequences, a Proteogenomics Endeavor -- Using Proteomics Bioinformatics Tools and Resources in Proteogenomic Studies -- Mutant Proteogenomics -- Proteogenomic Analysis of Single Amino Acid Polymorphisms in Cancer Research -- Developments for Personalized Medicine of Lung Cancer Subtypes: Mass Spectrometry-based Clinical Proteogenomic Analysis of Oncogenic Mutations -- Proteomics for the Study of Gastrointestinal Stromal Tumors -- Proteogenomics for the Comprehensive Analysis of Human Cellular and Serum Antibody Repertoires -- Antibody-Based Proteomics. 330 $aThis book highlights key technologies and identifies areas for further development in proteogenomics. The utility and usefulness of very large Omics data sets (Next Gen Sequencing of DNA, RNA-seq, ribosome profiling, mass spectrometry- and antibody-based proteomics) is discussed and opportunities and challenges of related bioinformatics applications are outlined. The reader will be able to appreciate the interdisciplinary nature of the continuously evolving area of proteogenomics, which has already grown beyond its original concept of verifying gene annotations by proteomics. The chapters presented in this book are arranged to offer a general overview, rather than to provide detailed descriptions of technologies. The selected applications will provide useful insight into the level of detail that can be obtained in relation to certain diseases areas, including cancer biology and personalized medicine. The readers will find that each chapter delivers a comprehensive approach to proteogenomics, each from the point of view of a specific application. Research scientists interested in innovative processes that can offer a unique and at the same time a more complete access to technological developments and concepts that in turn can contribute to a better understand biological functions should read this book. . 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v926 606 $aProteomics 606 $aMedical genetics 606 $aMass spectrometry 606 $aGene expression 606 $aProteomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L1403X 606 $aGene Function$3https://scigraph.springernature.com/ontologies/product-market-codes/B12030 606 $aMass Spectrometry$3https://scigraph.springernature.com/ontologies/product-market-codes/C11010 606 $aGene Expression$3https://scigraph.springernature.com/ontologies/product-market-codes/B12010 615 0$aProteomics. 615 0$aMedical genetics. 615 0$aMass spectrometry. 615 0$aGene expression. 615 14$aProteomics. 615 24$aGene Function. 615 24$aMass Spectrometry. 615 24$aGene Expression. 676 $a572.6 702 $aVégvári$b Ákos$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910253895503321 996 $aProteogenomics$92529026 997 $aUNINA