LEADER 03785nam  22005535  450 
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010   $a3-319-34148-0
024 7 $a10.1007/978-3-319-34148-4
035   $a(CKB)3710000000829533
035   $a(DE-He213)978-3-319-34148-4
035   $a(MiAaPQ)EBC4635302
035   $a(PPN)194806510
035   $a(EXLCZ)993710000000829533
100   $a20160809d2016      u|             0
101 0 $aeng
135   $aurnn#008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aGenome Editing$b[electronic resource] /$fedited by Kursad Turksen
205   $a1st ed. 2016.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016.
215   $a1 online resource (IX, 166 p. 24 illus. in color.)
311   $a3-319-34146-4 
320   $aIncludes bibliographical references at the end of each chapters and index.
327   $aGenome Editing with Targetable Nucleases -- CRISPR/Cas9 Approaches to Investigate the Non-coding Genome -- At the Conflux of Human Genome Engineering and Induced Pluripotency -- CRISPR/Cas9 and the Paradigm Shift in Mouse Genome Manipulation Technologies -- Genome Editing Technology in CRISPR/Cas System: How to Increase Knock-in Efficiency in Mouse Zygotes -- Developments in the Generation of Reporter Stem Cells -- Current Status of Genome Editing in Cardiovascular Medicine -- Using CRISPR-Cas9 Genome Editing to Enhance Cell Based Therapies for the Treatment of Diabetes Mellitus -- Genome Editing in the Retina: a Case Study in CRISPR for a Patient-Specific Autosomal Dominant Retinitis Pigmentosa Model -- Index.
330   $aThis timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text contextualizes these methods in treatment of cardiovascular disease, diabetes mellitus, retinitis pigmentosa, and others. The final chapters round out the book with a discussion of controversies and future directions. Genome Editing is an essential, of-the-moment contribution to this rapidly growing field. Drawing from a wealth of international perspectives, it presents novel techniques and applications for the engineering of the human genome. This book is essential reading for all clinicians and researchers in stem cells, regenerative medicine, genomics, biochemical and biomedical engineering- especially those interested in learning more about genome editing and applying it in a targeted, specific way.
606   $aRegenerative medicine
606   $aTissue engineering
606   $aStem cells
606   $aAnimal genetics
606   $aRegenerative Medicine/Tissue Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/L16080
606   $aStem Cells$3https://scigraph.springernature.com/ontologies/product-market-codes/L16010
606   $aAnimal Genetics and Genomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L32030
615  0$aRegenerative medicine.
615  0$aTissue engineering.
615  0$aStem cells.
615  0$aAnimal genetics.
615 14$aRegenerative Medicine/Tissue Engineering.
615 24$aStem Cells.
615 24$aAnimal Genetics and Genomics.
676   $a612.028
676   $a571.538
702   $aTurksen$b Kursad$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910253893203321
996   $aGenome Editing$92097477
997   $aUNINA