LEADER 05285nam 22006375 450 001 9910253884903321 005 20200702162357.0 010 $a3-319-22279-1 024 7 $a10.1007/978-3-319-22279-0 035 $a(CKB)3710000000636308 035 $a(EBL)4470793 035 $a(SSID)ssj0001665645 035 $a(PQKBManifestationID)16455008 035 $a(PQKBTitleCode)TC0001665645 035 $a(PQKBWorkID)15000603 035 $a(PQKB)11269346 035 $a(DE-He213)978-3-319-22279-0 035 $a(MiAaPQ)EBC4470793 035 $a(PPN)193445832 035 $a(EXLCZ)993710000000636308 100 $a20160401d2016 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aRNA/DNA and Cancer$b[electronic resource] /$fby Joseph G. Sinkovics 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource 311 $a3-319-22278-3 320 $aIncludes bibliographical references and index. 327 $aPreface. Introductions. I THE PRIMORDIAL RNA/DNA COMPLEX EVOLVING -- The Primordial Genes Are Conserved as Stem Cell Genes and Proto-Oncogenes -- The First Cells Ascend -- Eukaryotic Single Cells and the First Cell Communities Then and Now -- A Highly Effective Immune System Predating Adaptive Immunity -- Elements of Adaptive Immunity Self-Assemble -- The RNA/DNA Complex at Work -- YY Proteins -- Elusive Alleles -- The Long Trajectory of the IGF-like Receptor and Its Ligands -- Primordial Fused Genes Become Oncogenes and Encode Oncoproteins -- Performance in the Laboratory -- Inbuilt Errors not yet Corrected -- Errors or Inherent Attributes for the Sustenance of Unicellular Life -- Viral Genomic Insertions into the Host Cell?s Genome -- Viral and Cellular Proteins Interact -- Light Cast to Broken DNA, Its Repair, and Consequences -- Undisciplined Introns -- Elementary Epigenomics -- RNA/DNA: Bioengineers Supreme -- II THE ONCOGENOME -- Seamless Unity of the Nucleus and Cytoplasm: the Membranes Are Permeable -- Endogenously Initiated Immortalization is Welcome. Enforced Carcinogenesis by Exogenous Alien Initiator Is Resisted -- A Condensed Compendium -- ?Malignant Transformation? -- III THE HUMAN CEREBRAL CORTICAL DNA AGAINST CANCER CELL DNA -- Will the Human Cerebral Cortex Subdue the Oncogenome?- In Self-Defense, the Cancer Cell Reactivates Its Primordial Genome Loaded with Proviruses in Order to Mobilize All Its Remaining Survival Pathways -- The Cancer Cell Viewed as a Unicellular Parasite (an Amoeba) -- Astute Observers Withstand Derision -- ?Making Cancer History? at M.D. Anderson Hospital -- SUMMARY -- Appendix 1 -- Appendix 2 -- Index. . 330 $aIn this book, the author Joseph G. Sinkovics liberally shares his views on the cancer cell which he has been observing in vivo and in vitro, over a life time. Readers will learn how, as an inherent faculty of the RNA/DNA complex, the primordial cell survival pathways are endogenously reactivated in an amplified or constitutive manner in the multicellular host, and are either masquerading as self-elements or as placentas, to which the multicellular host is evolutionarily trained to extend full support. The host obliges. The author explains that there is no such evidence that ?malignantly transformed? human cells survive in nature. However, when cared for in the laboratory, these cells live and replicate as immortalized cultures. These cells retain their vitality upon storage in liquid nitrogen. One can only imagine an astrophysical environment in which such cells could survive; perhaps, first their seemingly humble exosomes would populate that environment. Immortal cell populations so created may survive as individuals, or may even re-organize themselves into multicellular colonies, as representatives of life for the duration of the Universe. This thought-provoking book is the work of a disciplined investigator and clinician with an impeccable reputation, and he enters a territory that very few if any before him have approached from the same angles. It will appeal to researchers with an interest in cell survival pathways and those researching cancer cells. . 606 $aCancer research 606 $aCell biology 606 $aImmunology 606 $aOncology   606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 615 0$aCancer research. 615 0$aCell biology. 615 0$aImmunology. 615 0$aOncology  . 615 14$aCancer Research. 615 24$aCell Biology. 615 24$aImmunology. 615 24$aOncology. 676 $a571.6 700 $aSinkovics$b Joseph G$4aut$4http://id.loc.gov/vocabulary/relators/aut$01064841 906 $aBOOK 912 $a9910253884903321 996 $aRNA$92541155 997 $aUNINA