LEADER 04660nam 22007095 450 001 9910253881503321 005 20231222115554.0 010 $a3-319-22708-4 024 7 $a10.1007/978-3-319-22708-5 035 $a(CKB)3710000000501083 035 $a(EBL)4089850 035 $a(SSID)ssj0001583910 035 $a(PQKBManifestationID)16264363 035 $a(PQKBTitleCode)TC0001583910 035 $a(PQKBWorkID)14865656 035 $a(PQKB)11339854 035 $a(DE-He213)978-3-319-22708-5 035 $a(MiAaPQ)EBC4089850 035 $a(PPN)190520280 035 $a(EXLCZ)993710000000501083 100 $a20151103d2016 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aSynthetic Biology /$fedited by Anton Glieder, Christian P. Kubicek, Diethard Mattanovich, Birgit Wiltschi, Michael Sauer 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (371 p.) 300 $aDescription based upon print version of record. 311 $a3-319-22707-6 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aXenobiotic life (artificial cells and cell like structures, biological nanostructures, XNA) -- Novel DNA and RNA (synthetic promoters, riboswitches, small RNAs, ribozymes, adaptamers, DNA walker, DNA machines) -- Expansion of the genetic code and protein building blocks (orthogonal mRNA-ribosome pairs, non canonical amino acids) -- DNA logics and circuit design (including sensors, TALORs, genome rewiring repressilator, oscillator, metabolator, ?Multicellular circuits?) -- Protein engineering (directed evolution, domain engineering) -- Synthetic metabolic pathways (engineered pathways, non natural pathways, scaffolding) -- Reengineered chassis cells (minimal organisms, platform hosts, minimal genomes, synthetic genomes) -- In silico simulation and design of complex metabolic and signalling networks -- Novel synthetic biomaterials -- Key methods for synthetic biology (assembly technologies, genome engineering technologies, DNA synthesis, Standardization) -- Public awareness and risk management. 330 $aThe emerging field of synthetic biology employs biotechnological approaches to recreate and enhance basic biological structures, intracellular processes and whole organisms. This book provides a comprehensive, up-to-date overview of the opportunities and challenges of this complex field of biotechnology, which combines various scientific disciplines. It addresses a broad range of topics, including redesigning complex metabolic pathways, DNA/RNA and protein engineering, as well as novel synthetic biomaterials. It discusses both ?bottom up? and ?top down? approaches and presents the latest genome engineering tools with predictions about how these could change our way of thinking and working. Since the use of synthetic biology raises a number of ethical questions, a chapter is devoted to public awareness and risk management. The book is of interest to scientists from both academia and industry, as well as PhD students and postdocs working in the field. 606 $aSystems biology 606 $aBiochemical engineering 606 $aBiomaterials 606 $aGenetic engineering 606 $aSystems Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L15010 606 $aBiochemical Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/C12029 606 $aBiomaterials$3https://scigraph.springernature.com/ontologies/product-market-codes/Z13000 606 $aGenetic Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/C12037 615 0$aSystems biology. 615 0$aBiochemical engineering. 615 0$aBiomaterials. 615 0$aGenetic engineering. 615 14$aSystems Biology. 615 24$aBiochemical Engineering. 615 24$aBiomaterials. 615 24$aGenetic Engineering. 676 $a570 676 $a660.6 702 $aGlieder$b Anton$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aKubicek$b Christian P$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMattanovich$b Diethard$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aWiltschi$b Birgit$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSauer$b Michael$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910253881503321 996 $aSynthetic Biology$91413076 997 $aUNINA