LEADER 03763nam 22006975 450 001 9910253880103321 005 20230810185029.0 010 $a3-319-26133-9 024 7 $a10.1007/978-3-319-26133-1 035 $a(CKB)3880000000021665 035 $a(EBL)4205813 035 $a(SSID)ssj0001596849 035 $a(PQKBManifestationID)16297038 035 $a(PQKBTitleCode)TC0001596849 035 $a(PQKBWorkID)14886329 035 $a(PQKB)10946095 035 $a(DE-He213)978-3-319-26133-1 035 $a(MiAaPQ)EBC4205813 035 $a(PPN)190885300 035 $a(EXLCZ)993880000000021665 100 $a20151226d2016 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aB Cell Receptor Signaling /$fedited by Tomohiro Kurosaki, Jürgen Wienands 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (231 p.) 225 1 $aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v393 300 $aDescription based upon print version of record. 311 $a3-319-26131-2 320 $aIncludes bibliographical references at the end of each chapters. 327 $aAssembly and function of the precursor B-cell receptor -- Receptor Dissociation and B cell activation -- Molecular mechanisms of B cell antigen gathering and endocytosis -- BTK signaling in B cell differentiation and autoimmunity -- The memory function of the B cell antigen receptor -- PI3K signaling in normal B cells and chronic lymphocytic leukemia (CLL) -- Role of Calcium Signaling in B Cell Activation and Biolog -- Roles of the NF-kappaB pathway in B-lymphocyte biology -- MAP kinase cascades in antigen receptor signaling and physiology. 330 $aThis volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton?s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases. 410 0$aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v393 606 $aImmunology 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aCancer 606 $aImmunology 606 $aBiomedical Research 606 $aCancer Biology 615 0$aImmunology. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aCancer. 615 14$aImmunology. 615 24$aBiomedical Research. 615 24$aCancer Biology. 676 $a616.0798 702 $aKurosaki$b Tomohiro$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aWienands$b Jürgen$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910253880103321 996 $aB Cell Receptor Signaling$92527574 997 $aUNINA