LEADER 04304nam 22005295 450 001 9910253876403321 005 20200704165319.0 010 $a4-431-56027-0 024 7 $a10.1007/978-4-431-56027-2 035 $a(CKB)3710000000727265 035 $a(DE-He213)978-4-431-56027-2 035 $a(MiAaPQ)EBC4550106 035 $a(PPN)194377245 035 $a(EXLCZ)993710000000727265 100 $a20160609d2016 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aSynthetic Immunology /$fedited by Takeshi Watanabe, Yousuke Takahama 205 $a1st ed. 2016. 210 1$aTokyo :$cSpringer Japan :$cImprint: Springer,$d2016. 215 $a1 online resource (XI, 200 p. 45 illus., 41 illus. in color.) 311 $a4-431-56025-4 320 $aIncludes bibliographical references at the end of each chapters. 327 $a1. Overview (Michael Reth) -- 2. Development and regeneration of HSCs (Hiromitsu Nakauchi) -- 3. Development and regeneration of T cells (Hiroshi Kawamoto) -- 4. Controlling the thymus development (Richard Boyd) -- 5. Artificial thymus microenvironment (JC Zuniga-Pflucker) -- 6. Controlling lymph node development (Sergio Lira) -- 7. Artificial lymph nodes (Takeshi Watanabe) -- 8. Lymph nodes as surrogate organ (Eric Lagasse) -- 9. Tissue reconstitution by 3D bio-printer (Makoto Nakamura) -- 10. Reconstitution of human immune system in the mouse (Fumihiko Ishikawa). 330 $aThis book reviews the emerging studies of synthetic immunology, including the development and regeneration of immune cells, immune organ development and artificial regeneration, and the synthetic approach towards understanding human immune system. Immunology has developed rapidly over the last 50 years through the incorporation of new methods and concepts in cell and molecular biology, genetics, genomics and proteomics. This progress is the result of works by many excellent researchers all over the world. Currently, immunological research has accumulated detailed knowledge on basic mechanisms of immunity and is in the process to change medical practices. Yet, due to the enormous complexity of the immune system, many aspects on the regulation and function of this system remain unknown. Synthetic biology uses gain-of-function rather than loss-of-function approaches. The goals of synthetic biology can be described in a simple phrase ?rebuild, alter, and understand," namely, to rebuild minimal functional systems using well-defined parts from nature and then to perturb the system to understand its working principles. Given the richness of accumulated knowledge in molecular and cellular mechanisms of the immune system, we now begin adapting the concepts of synthetic biology to immunology. An immune response is a spatiotemporal phenomenon occurring at a given time and at a specialized place in the body. One goal of synthetic immunology is to reconstruct artificial microenvironments for better understanding of an immune response. We hope this yet-to-be-experimental approach of synthetic immunology and the compilation of this book will aid our further understanding of the immune system and future devising the tools to manipulate the immune system for therapy and prevention of the diseases. 606 $aImmunology 606 $aSystems biology 606 $aBiomedical engineering 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aSystems Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L15010 606 $aBiomedical Engineering and Bioengineering$3https://scigraph.springernature.com/ontologies/product-market-codes/T2700X 615 0$aImmunology. 615 0$aSystems biology. 615 0$aBiomedical engineering. 615 14$aImmunology. 615 24$aSystems Biology. 615 24$aBiomedical Engineering and Bioengineering. 676 $a616.079 702 $aWatanabe$b Takeshi$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aTakahama$b Yousuke$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910253876403321 996 $aSynthetic Immunology$92532373 997 $aUNINA