LEADER 00771nam0-22002651i-450- 001 990003558500403321 005 20001010 035 $a000355850 035 $aFED01000355850 035 $a(Aleph)000355850FED01 035 $a000355850 100 $a20000920d1963----km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $aHistoire economique de Geneve des origines un debit du XVIe siecle$fBabel Antony 210 $aGeneve$cs.e.$d1963 215 $atomi I 700 1$aBabel,$bAntony$0129504 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990003558500403321 952 $aSE 055.07.05-$b032016$fDECSE 959 $aDECSE 996 $aHistoire economique de Geneve des origines un debit du XVIe siecle$9493213 997 $aUNINA LEADER 04403nam 22005535 450 001 9910253876003321 005 20200701231652.0 010 $a94-017-7741-1 024 7 $a10.1007/978-94-017-7741-4 035 $a(CKB)3710000000734937 035 $a(DE-He213)978-94-017-7741-4 035 $a(MiAaPQ)EBC6314801 035 $a(MiAaPQ)EBC5579603 035 $a(Au-PeEL)EBL5579603 035 $a(OCoLC)951775533 035 $a(PPN)194376656 035 $a(EXLCZ)993710000000734937 100 $a20160606d2016 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMechanisms of Gene Regulation /$fby Carsten Carlberg, Ferdinand Molnár 205 $a2nd ed. 2016. 210 1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2016. 215 $a1 online resource (XVI, 211 p. 82 illus. in color.) 311 $a94-017-7740-3 320 $aIncludes bibliographical references. 327 $aOverview: What is gene expression? -- The impact of chromatin -- The basal transcriptional machinery -- Transcription factors -- Linking signal transduction and gene regulation -- Switching genes on and off at the example of nuclear receptors -- Mapping the genome -- Chromatin modifiers -- Genomic imprinting -- The epigenome -- Chromatin remodeling -- Chromatin architecture -- Regulatory RNA. 330 $aThis textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation. The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule stating that ?a picture tells more than thousand words?. The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories. 606 $aGene expression 606 $aProteins 606 $aGene Expression$3https://scigraph.springernature.com/ontologies/product-market-codes/B12010 606 $aProtein Structure$3https://scigraph.springernature.com/ontologies/product-market-codes/L14050 615 0$aGene expression. 615 0$aProteins. 615 14$aGene Expression. 615 24$aProtein Structure. 676 $a572.865 700 $aCarlberg$b Carsten$4aut$4http://id.loc.gov/vocabulary/relators/aut$0849346 702 $aMolnár$b Ferdinand$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910253876003321 996 $aMechanisms of Gene Regulation$92496674 997 $aUNINA