LEADER 04373nam 22005535 450 001 9910253874903321 005 20200702165818.0 010 $a3-319-30415-1 024 7 $a10.1007/978-3-319-30415-1 035 $a(CKB)3710000000734930 035 $a(DE-He213)978-3-319-30415-1 035 $a(MiAaPQ)EBC6312493 035 $a(MiAaPQ)EBC5578704 035 $a(Au-PeEL)EBL5578704 035 $a(OCoLC)951979595 035 $a(PPN)194380904 035 $a(EXLCZ)993710000000734930 100 $a20160611d2016 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aNutrigenomics /$fby Carsten Carlberg, Stine Marie Ulven, Ferdinand Molnár 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (XXI, 222 p. 103 illus., 101 illus. in color.) 311 $a3-319-30413-5 327 $aNutrition and common diseases -- Human genomic variation -- Sensing nutrition -- Nutrigenomics: Adapting the human genome to dietary changes and personalized nutrition -- Nutritional epigenomics -- Nutritional signaling and aging -- Chronic inflammation and metabolic stress -- Obesity -- Glucose homeostasis, insulin resistance and ? cell failure -- Diabetes -- Hypertension, atherosclerosis and dyslipidemias -- Metabolic syndrome. . 330 $aThe fascinating area of Nutrigenomics describes this daily communication between diet, food and nutrients, their metabolites and our genome. This book describes how nutrition shapes human evolution and demonstrates its consequences for our susceptibility to diseases, such as diabetes and atherosclerosis. Inappropriate diet can yield stress for our cells, tissues and organs and then it is often associated with low-grade chronic inflammation. Overnutrition paired with physical inactivity leads to overweight and obesity and results in increased burden for a body that originally was adapted for a life in the savannas of East Africa. Therefore, this textbook does not discuss a theoretical topic in science, but it talks about real life, and our life-long ?chat? with diet. We are all food consumers, thus each of us is concerned by the topic of this book and should be aware of its mechanisms. The purpose of this book is to provide an overview on the principles of nutrigenomics and their relation to health or disease. We are not aiming to compete with more comprehensive textbooks on molecular nutrition, evolutionary biology, genomics, gene regulation or metabolic diseases, but rather will focus on the essentials and will combine, in a compact form, elements from different disciplines. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule ?a picture tells more than thousand words?. The content of this book is based on the lecture course ?Nutrigenomics?, which is held since 2003 once per year by Prof. Carlberg at the University of Eastern Finland in Kuopio. The book is subdivided into three sections and twelve chapters. Following the "Introduction" there are sections on the "Molecular genetic basis" and the "Links to disease", which take a view on nutrigenomics from the perspective of molecular mechanisms or from the causes of metabolic diseases, respectively. Besides its value as a textbook, Nutrigenomics will be a usefull reference for individuals working in biomedicine. 606 $aMolecular biology 606 $aClinical nutrition 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aClinical Nutrition$3https://scigraph.springernature.com/ontologies/product-market-codes/H33140 615 0$aMolecular biology. 615 0$aClinical nutrition. 615 14$aMolecular Medicine. 615 24$aClinical Nutrition. 676 $a612.3 700 $aCarlberg$b Carsten$4aut$4http://id.loc.gov/vocabulary/relators/aut$0849346 702 $aUlven$b Stine Marie$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aMolnár$b Ferdinand$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910253874903321 996 $aNutrigenomics$92509301 997 $aUNINA