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010   $a3-319-23476-5
024 7 $a10.1007/978-3-319-23476-2
035   $a(CKB)3710000000539328
035   $a(EBL)4199775
035   $a(SSID)ssj0001596841
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035   $a(PQKBTitleCode)TC0001596841
035   $a(PQKBWorkID)14886361
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035   $a(DE-He213)978-3-319-23476-2
035   $a(MiAaPQ)EBC4199775
035   $a(PPN)19088102X
035   $a(EXLCZ)993710000000539328
100   $a20151216d2016      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aABC Transporters - 40 Years on /$fedited by Anthony M. George
205   $a1st ed. 2016.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016.
215   $a1 online resource (384 p.)
300   $aDescription based upon print version of record.
311   $a3-319-23475-7 
320   $aIncludes bibliographical references.
327   $aABC Importers -- Inborn errors and potential correction of the cellular expression and localization of medically important ABC transporters -- Human ABC transporter ABCC11: Molecular mechanistic, pharmacological, and anthropological aspects -- Biology of mitochondrial ABCs and their contribution to pathology -- ABC transporters and multidrug resistance in fungi and yeast -- Structural and mechanistic insights into modulation of P-glycoprotein (ABCB1)function by tyrosine kinase inhibitors -- Techniques for the purification of ABC transporters -- HDAC inhibitors and MDR ABC transporters -- The role of polymorphisms in P-glycoprotein (ABCB1) on function -- Interaction of ABC transporters with drugs -- ABC insights from CFTR.
330   $aThis book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within which chemotherapy failure is observed in about 50% of cases. Together with its complex pharmacology, and even a suspected role in Alzheimer?s disease, this ABC transporter still eludes a clinical solution to its multidrug resistance property. ABC transporters are integral membrane active proteins and they belong to one of the largest protein families across all species. Their myriad roles encompass the import or export of a diverse range of allocrites, including ion, nutrients, peptides, polysaccharides, lipids, and xenobiotics. They are of major medical importance with many members elaborating multidrug resistance in bacteria, fungi, yeast, parasites, and humans. Other ABC transporters are involved in a number of inherited diseases, including cystic fibrosis, macular degeneration, gout, and several other metabolic disorders.
606   $aCell membranes
606   $aBiophysics
606   $aBiophysics
606   $aBiochemistry
606   $aDrug resistance
606   $aMembrane Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16050
606   $aBiological and Medical Physics, Biophysics$3https://scigraph.springernature.com/ontologies/product-market-codes/P27008
606   $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005
606   $aDrug Resistance$3https://scigraph.springernature.com/ontologies/product-market-codes/B16020
615  0$aCell membranes.
615  0$aBiophysics.
615  0$aBiophysics.
615  0$aBiochemistry.
615  0$aDrug resistance.
615 14$aMembrane Biology.
615 24$aBiological and Medical Physics, Biophysics.
615 24$aBiochemistry, general.
615 24$aDrug Resistance.
676   $a570
702   $aGeorge$b Anthony M$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910253873703321
996   $aABC Transporters - 40 Years on$92532371
997   $aUNINA