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010   $a3-319-27820-7
024 7 $a10.1007/978-3-319-27820-9
035   $a(CKB)3710000000596531
035   $a(EBL)4403222
035   $a(SSID)ssj0001653828
035   $a(PQKBManifestationID)16433475
035   $a(PQKBTitleCode)TC0001653828
035   $a(PQKBWorkID)14982418
035   $a(PQKB)11514755
035   $a(DE-He213)978-3-319-27820-9
035   $a(MiAaPQ)EBC4403222
035   $a(PPN)192219421
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100   $a20160209d2016      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 14$aThe Role of Microenvironment in the Control of Tumor Angiogenesis /$fby Domenico Ribatti
205   $a1st ed. 2016.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016.
215   $a1 online resource (97 p.)
300   $aDescription based upon print version of record.
311   $a3-319-27818-5 
320   $aIncludes bibliographical references and index.
327   $aPrelims -- Tumor microenvironment -- Tumor blood vessels and tumor endothelial cells -- Tumor angiogenesis -- Inflammatory cells in tumor microenvironment -- Therapeutic strategies, the concept of ?normalization? and the role of VEGF inhibition -- Index. .
330   $aThis work describes the importance of tumor microenvironment in favouring tumor progression and angiogenesis. Under physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the vascular microenvironment and requires the functional activities of a number of molecules, including angiogenic factors, extracellular matrix proteins, adhesion molecules and proteolytic enzymes. In normal tissues, vascular quiescence is maintained by the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli. Tumor angiogenesis is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic cells of specific growth factors for endothelial cells, that stimulate the growth of the blood vessels of the host or the down-regulation of natural angiogenesis inhibitors. In particular, the inflammatory infiltrate may contribute to tumor angiogenesis, and there are many reports of associations between tumor inflammatory infiltrate, vascularity and prognosis. New therapeutic approaches have been developed with the aim to control tumor angiogenesis through targeting of different components of tumor microenvironment.
606   $aCancer research
606   $aOncology  
606   $aPathology
606   $aPharmacotherapy
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
606   $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160
606   $aPathology$3https://scigraph.springernature.com/ontologies/product-market-codes/H4800X
606   $aPharmacotherapy$3https://scigraph.springernature.com/ontologies/product-market-codes/H69000
615  0$aCancer research.
615  0$aOncology  .
615  0$aPathology.
615  0$aPharmacotherapy.
615 14$aCancer Research.
615 24$aOncology.
615 24$aPathology.
615 24$aPharmacotherapy.
676   $a610
700   $aRibatti$b Domenico$4aut$4http://id.loc.gov/vocabulary/relators/aut$0793065
906   $aBOOK
912   $a9910253869103321
996   $aThe Role of Microenvironment in the Control of Tumor Angiogenesis$92529380
997   $aUNINA