LEADER 03996nam 22004815 450 001 9910253868003321 005 20200701130825.0 010 $a3-319-32805-0 024 7 $a10.1007/978-3-319-32805-8 035 $a(CKB)3710000000717857 035 $a(DE-He213)978-3-319-32805-8 035 $a(MiAaPQ)EBC4533866 035 $a(PPN)194074390 035 $a(EXLCZ)993710000000717857 100 $a20160528d2016 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aProtein Targeting Compounds$b[electronic resource] $ePrediction, Selection and Activity of Specific Inhibitors /$fedited by Thomas Böldicke 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (VIII, 288 p. 49 illus., 31 illus. in color.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v917 311 $a3-319-32804-2 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aIntroduction -- Part I Methods of Structure Prediction -- Chapter 1 In Silico Prediction of Target-Inhibitor Interactions -- Part II Antibodies -- Chapter 2 Antibodies and Selection of Monoclonal Antibodies -- Chapter 3 Selection of Recombinant Human Antibodies -- Chapter 4 Selection of Recombinant Human Antibodies against Toxins and Viruses -- Chapter 5 Recent Advances with ER Targeted Intrabodies -- Chapter 6 Therapeutic Blocking Antibodies against Oncogenic Receptors and Growth Factors -- Chapter 7 Synthetic Cystine-Knot Miniproteins-Valuable Scaffolds for Polypeptide Engineering -- Part III Peptides, Small Molecules and Aptamers -- Chapter 8 Peptides and Peptide Analogs to Inhibit Protein -- Chapter 9 Allosteric Modulators of the Class A G Protein coupled Receptors -- Chapter 10 Phosphatases: Their Roles in Cancer and their Chemical Modulators -- Chapter 11 Selection and Application of Aptamers and Intramers -- Part IV Angiogenesis Inhibitors -- Chapter 12 Inhibitors of Angiogenesis. 330 $aThis book presents an overview of the most relevant protein knockdown techniques. Readers will find a description of the generation and use of recombinant human antibodies, ER intrabodies and peptides as well as a description of the working mechanism and potential of the inhibitory action of each of these molecules. The book will also describe the selection and activity of a number of phosphatases, aptamers and allosteric modulators, focusing on A G protein coupled receptors. The book starts with a chapter on the in silico prediction of target-inhibitor interactions. Key aspects of this book are: - Selection strategies for monoclonal and recombinant human antibodies - Selection strategies for ER intrabodies, peptides and aptamers - Examples of the most efficient inhibitors and their applications in protein biochemistry and cell biology - Antibodies for cancer therapy and inhibitors of angiogenesis. The book will be of great interest to scientists and students working in the life sciences on all areas related to protein biology. The variety of methods to modulate the activities of specific proteins which are introduced here will be of great benefit to the reader who is interested in general protein research or to readers who have very specific protein related questions. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v917 606 $aImmunology 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 615 0$aImmunology. 615 14$aImmunology. 676 $a574.19296 702 $aBöldicke$b Thomas$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910253868003321 996 $aProtein Targeting Compounds$92528854 997 $aUNINA