LEADER 04436nam 22006135 450 001 9910253866503321 005 20251113210925.0 010 $a3-319-26239-4 024 7 $a10.1007/978-3-319-26239-0 035 $a(CKB)3710000000657944 035 $a(EBL)4526232 035 $a(DE-He213)978-3-319-26239-0 035 $a(MiAaPQ)EBC4526232 035 $a(PPN)194078310 035 $a(EXLCZ)993710000000657944 100 $a20160509d2016 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCellular Ageing and Replicative Senescence /$fedited by Suresh I.S. Rattan, Leonard Hayflick 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (358 p.) 225 1 $aHealthy Ageing and Longevity,$x2199-9015 300 $aDescription based upon print version of record. 311 08$a3-319-26237-8 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aPreface -- Section I  History and origins --  Origins of the Hayflick system, the phenomenon and the limit -- Early testing and development of the Hayflick system -- Section II Serial passaging and progressive changes -- Slowing down of the cell cycle -- Ageing of cells in the centenarians and long-lived -- Aging of the stem cells -- Aging and senescence in the immune cells in vitro and in vivo -- Accelerated cellular aging in progeroid syndromes -- Telomere and genomic instability -- Mechanistic explanation for cellular aging in vitro: the commitment theory -- Modelling cellular aging senescence -- Section-III Regulation, and senescence -- Cell cycle checkpoints and regulators of senescence -- Oxidative stress and cellular ageing -- Biomarkers of replicative senescence revisited -- Cellular aging and tumour regulation -- Declining Protein turnover and degradation -- Section IV Modulating the system -- Stress induced premature senescence (SIPS) -- Mild stress-induced hormesis -- Food, hormones and growth factors in cellular aging -- sncRNAs in cellular aging and senescence -- Elimination of senescent cells for rejuvenation -- Section-V RECAPITULATION -- The past, present and the future of cellular aging and replicative senescence -- Index. 330 $aThis book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it. 410 0$aHealthy Ageing and Longevity,$x2199-9015 606 $aMolecular genetics 606 $aCytology 606 $aGeriatrics 606 $aMolecular Genetics 606 $aCell Biology 606 $aGeriatrics 615 0$aMolecular genetics. 615 0$aCytology. 615 0$aGeriatrics. 615 14$aMolecular Genetics. 615 24$aCell Biology. 615 24$aGeriatrics. 676 $a612.67 702 $aRattan$b Suresh I.S$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aHayflick$b Leonard$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910253866503321 996 $aCellular Ageing and Replicative Senescence$92526701 997 $aUNINA