LEADER 04713nam 22005775 450 001 9910253864503321 005 20200702125801.0 010 $a3-319-30654-5 024 7 $a10.1007/978-3-319-30654-4 035 $a(CKB)3710000000667137 035 $a(DE-He213)978-3-319-30654-4 035 $a(MiAaPQ)EBC4526692 035 $a(PPN)194074366 035 $a(EXLCZ)993710000000667137 100 $a20160510d2016 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCancer and Zebrafish $eMechanisms, Techniques, and Models /$fedited by David M. Langenau 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (XII, 552 p. 85 illus. in color.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v916 311 $a3-319-30652-9 320 $aIncludes bibliographical references at the end of each chapters. 327 $aPart 1. Powers Of The Zebrafish Model -- 1. Uncharted Waters: Zebrafish Cancer Models Navigate A Course for Oncogene Discovery -- 2. The Toolbox for Conditional Zebrafish Cancer Models -- 3. Approaches to Inactivate Genes in Zebrafish -- 4. Tumor Suppressors in Zebrafish: From Tp53 To Pten and Beyond -- 5. Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish -- 6. Genomic Approaches To Zebrafish Cancer -- 7. Transcriptomic Analyses in Zebrafish Cancer Models for Global Gene Expression and Pathway Discovery -- 8. Zebrafish Discoveries in Cancer Epigenetics -- 9. Lymphatics, Cancer and Zebrafish -- 10. In Vivo Imaging of Cancer in Zebrafish -- 11. Imaging Cancer Angiogenesis and Metastasis in A Zebrafish Embryo Model -- 12. Allograft Cancer Cell Transplantation in Zebrafish -- 13. The Zebrafish Xenograft Platform: Evolution of A Novel Cancer Model and Preclinical Screening Tool -- 14. Automation of Technology for Cancer Research -- Part 2. Cancer Models in Fish -- 15. Zebrafish Models Of Human Leukemia: Technological Advances and Mechanistic Insights -- 16. Zebrafish Rhabdomyosarcoma -- 17. Baiting for Cancer: Using The Zebrafish as A Model in Liver And Pancreatic Cancer -- 18. How Zebrafish Are Helping Us To Target Colorectal Cancer -- 19. Zebrafish Melanoma -- 20. Neuroblastoma and Its Zebrafish Model -- 21. Zebrafish Germ Cell Tumors -- 22. Malignant Peripheral Nerve Sheath Tumors -- 23. Xiphophorus and Medaka Cancer Models. 330 $aThis volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncogene and tumor suppressor discovery, chemical genetic approaches, genomics, epigenetics, cancer imaging, and cell transplantation. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish cancer models, including T cell leukemia, rhabdomyosarcoma, liver and pancreatic cancer, melanoma, neuroblastoma, germ cell tumors, and malignant peripheral sheath tumors. A chapter is also dedicated to the development and utilization of other piscine models of cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and cancer, providing a much needed resource on the powerful attributes of the zebrafish model system. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v916 606 $aCancer research 606 $aMedical genetics 606 $aAnimal anatomy 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aGene Function$3https://scigraph.springernature.com/ontologies/product-market-codes/B12030 606 $aAnimal Anatomy / Morphology / Histology$3https://scigraph.springernature.com/ontologies/product-market-codes/L25015 615 0$aCancer research. 615 0$aMedical genetics. 615 0$aAnimal anatomy. 615 14$aCancer Research. 615 24$aGene Function. 615 24$aAnimal Anatomy / Morphology / Histology. 676 $a591.4 702 $aLangenau$b David M$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910253864503321 996 $aCancer and Zebrafish$92524221 997 $aUNINA