LEADER 04291 am 22007933u 450 001 9910231247003321 005 20230125225226.0 010 $a3-319-60192-X 024 7 $a10.1007/978-3-319-60192-2 035 $a(CKB)4100000000587449 035 $a(DE-He213)978-3-319-60192-2 035 $a(MiAaPQ)EBC5592014 035 $a(Au-PeEL)EBL5592014 035 $a(OCoLC)1004664421 035 $a(MiAaPQ)EBC6422738 035 $a(Au-PeEL)EBL6422738 035 $z(PPN)258854340 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/47145 035 $a(PPN)20453433X 035 $a(EXLCZ)994100000000587449 100 $a20170914d2017 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGenome Editing in Neurosciences$b[electronic resource] /$fedited by Rudolf Jaenisch, Feng Zhang, Fred Gage 205 $a1st ed. 2017. 210 $cSpringer Nature$d2017 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (XI, 123 p. 16 illus. in color.) 225 1 $aResearch and Perspectives in Neurosciences,$x0945-6082 311 $a3-319-60191-1 327 $aIntroduction -- In vitro modeling of complex neurological diseases -- Aquatic model organisms in neurosciences : the genome editing revolution -- Genome-wide genetic screening in the mammalian CNS -- CRISPR/Cas9-mediated Knockin and Knockout in Zebrafish -- Dissecting the role of synaptic proteins with CRISPR -- Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer -- Neuroscience research using non-human primate models and genome editing -- Multiscale genome engineering: Genome-wide screens and targeted approaches -- Using Genome Engineering to Understand Huntington?s Disease -- Therapeutic gene editing in muscles and muscle stem cells. 330 $aThis book is open access under a CC BY 4.0 license. Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome editing to address important challenges in neuroscience, including basic biology in model organisms that has the power to reveal systems-level insight into how the nervous system develops and functions as well as research focused on understanding and treating human neurological disorders. 410 0$aResearch and Perspectives in Neurosciences,$x0945-6082 606 $aHuman genetics 606 $aNeurosciences 606 $aBiomedical engineering 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aBiomedical Engineering/Biotechnology$3https://scigraph.springernature.com/ontologies/product-market-codes/B24000 610 $aCRISPR 610 $amuscular dystrophy 610 $aParkinson's disease 610 $aDNA 610 $aRett syndrome 610 $adouble-strand breaks 610 $aHuntington's disease 610 $agenetic engineering 615 0$aHuman genetics. 615 0$aNeurosciences. 615 0$aBiomedical engineering. 615 14$aHuman Genetics. 615 24$aNeurosciences. 615 24$aBiomedical Engineering/Biotechnology. 676 $a611.01816 676 $a599.935 700 $aFeng Zhang$4auth$01355929 702 $aJaenisch$b Rudolf$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aZhang$b Feng$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aGage$b Fred$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910231247003321 996 $aGenome Editing in Neurosciences$93360038 997 $aUNINA