LEADER 02324nam 2200349z- 450 001 9910227350003321 005 20231214133451.0 035 $a(CKB)4100000000883833 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/41040 035 $a(EXLCZ)994100000000883833 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aApplication of Antigen Cross-Presentation Research into Patient Care 210 $cFrontiers Media SA$d2017 215 $a1 electronic resource (124 p.) 225 1 $aFrontiers Research Topics 311 $a2-88945-191-7 330 $aThe activation of adaptive immune responses requires the processing and presentation of protein antigens to lymphocytes. Especially dendritic cells are effective at display of antigen-derived peptides in the form of immunogenic peptide/MHC complexes to CD4 and CD8-positive T cells, and can stimulate even naive T cells to clonally expand. During the last 40 years, mechanisms that facilitate antigen processing and presentation were clarified, mostly from work in cell lines and mouse models. From mouse-based work, it is now clear that dendritic cells represent a collection of specialized cell subsets that are particularly well endowed to stimulate antigen transport to distinct tissue locations, to transfer antigens between cellular subsets or to trigger T cell responses. Dendritic cell subsets hold great promise for therapeutic application, for example as dendritic cell-based vaccines to bolster immune responses against viruses or malignant growths. Hurdles remain that preclude the efficient application of high quality pre-clinical research into standardized patient care. In this research topic, efforts in dendritic cell research and dendritic cell-based vaccines are discussed, from both pre-clinical and application points of view. 610 $aclinical translation 610 $across-presentation 610 $aVaccination 610 $aImmunotherapy 610 $adendritic cell 700 $aMarianne Boes$4auth$01301444 906 $aBOOK 912 $a9910227350003321 996 $aApplication of Antigen Cross-Presentation Research into Patient Care$93025856 997 $aUNINA