LEADER 02766nam  2200445z- 450 
001 9910227349303321
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035   $a(CKB)4100000000883840
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/61527
035   $a(oapen)doab61527
035   $a(EXLCZ)994100000000883840
100   $a20202102d2017      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aUnderstanding Crohn's Disease: Immunity, Genes and Microbes
210   $cFrontiers Media SA$d2017
215   $a1 online resource (126 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88945-214-X 
330   $aCrohn's disease (CD) is a chronic, relapsing, inflammatory bowel disease resulting in considerable morbidity and reduced quality of life. Although still under intense debate, CD seems to result from an enhanced and uncontrolled immune response to the gut microbiota. CD is thought to be multifactorial depending on genetic and environmental determinants. In recent years, nearly 100 single nucleotide polymorphisms (SNPs) were associated with increased risk of developing CD (some of the SNPs also associated with susceptibility to ulcerative colitis, another type of IBD). These SNPs are mostly located in genes involved in innate and adaptive immunity mechanisms, such as autophagy, expression of pattern-recognition receptors and citokine signaling. Epigenetics is also probably playing a role in CD susceptibility, as it is sensitive to environmental conditions and may mediate gene-environment interactions. Environmental factors possibly involved in CD development include diet, gut microbiota composition and infection with specific pathogens, of which the most consistently associated to CD are Mycobacterium avium subsp. paratuberculosis and adherent-invasive Escherichia coli. This Topic aimed at bringing together contributions covering different genetic, epigenetic, immunological and microbial processes involved in the development of CD, helping to drive forward the understanding of CD immunopahtology.
517   $aUnderstanding Crohn's Disease
606   $aMedicine and Nursing$2bicssc
610   $aCrohn's disease
610   $aepigenetics
610   $agene polymorphisms
610   $aintestinal microbiota
610   $amucosal immune system
610   $amutritional modulation
610   $aT cells
615  7$aMedicine and Nursing
700   $aFernando Magro$4auth$01301497
702   $aNair Campos$4auth
702   $aAmelia Sarmento$4auth
906   $aBOOK
912   $a9910227349303321
996   $aUnderstanding Crohn's Disease: Immunity, Genes and Microbes$93025915
997   $aUNINA