LEADER 02447nam  2200385z- 450 
001 9910227348903321
005 20231214133415.0
035   $a(CKB)4100000000883844
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/57918
035   $a(EXLCZ)994100000000883844
100   $a20202102d2017      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aRedox Regulation in Skeletal Muscle Aging and Exercise
210   $cFrontiers Media SA$d2017
215   $a1 electronic resource (101 p.)
225 1 $aFrontiers Research Topics
311   $a2-88945-196-8 
330   $aSkeletal muscle represents the largest organ of the human body and comprises about 40% of total body mass in humans. Even in people who ?age well?, there is a noticeable loss of muscle strength and function that accelerates dramatically after the age of 60, a major factor in the reduction in life quality for the aging population. One of the most effective interventions to maintain muscle mass and function is through exercise. Skeletal muscle generates reactive oxygen and reactive nitrogen (ROS/RNS) species in response to muscle contractions. The concentration and species of ROS/RNS generated can depend on the age and fitness of the individual, muscle fibre type and the intensity of the muscle contractions. ROS/RNS generate unique signaling cascades that are not only essential in skeletal muscle contraction and adaptation but also play a role in a wide array of cell processes including cell proliferation, protein synthesis/degradation, immune response and antioxidant defense. ROS/RNS generated by contractions are involved in a co-ordinated local response that is tightly controlled at all levels from generation to detoxification. This collection of original articles and reviews highlights investigations that measure different aspects of the redox response of skeletal muscle to aging and exercise.
610   $aMitochondria
610   $aSternohyoid muscle
610   $auremic myopathy
610   $asphingomyelinase
610   $aMuscle Fatigue
610   $asirt3
610   $aCalveolin-3
610   $aNADPH Oxidase
700   $aBrian McDonagh$4auth$01313336
906   $aBOOK
912   $a9910227348903321
996   $aRedox Regulation in Skeletal Muscle Aging and Exercise$93031301
997   $aUNINA