LEADER 02919nam  2200445z- 450 
001 9910227348203321
005 20210211
035   $a(CKB)4100000000883851
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/50092
035   $a(oapen)doab50092
035   $a(EXLCZ)994100000000883851
100   $a20202102d2017      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aIn Vivo Imaging in Pharmacological Research
210   $cFrontiers Media SA$d2017
215   $a1 online resource (222 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88945-237-9 
330   $aThe discovery and development of a biological active molecule with therapeutic properties is an ever increasing complex task, highly unpredictable at the early stages and marked, in the end, by high rates of failure. As a consequence, the overall process leading to the production of a successful drug is very costly. The improvement of the net outcome in drug discovery and development would require, amongst other important factors, a good understanding of the molecular events that characterize the disease or pathology in order to better identify likely targets of interest, to optimize the interaction of an active agent (small molecule or macromolecule of natural or synthetic origin) with those targets, and to facilitate the study of the pharmacokinetics, pharmacodynamics and toxicity of an active agent in suitable models and in human subjects. The objective of this Research Topic is to highlight new developments and applications of imaging techniques with the objective of performing pharmacological studies in vivo, in animal models and in humans. In the domain of drug discovery, the pharmacological and biomedical questions constitute the center of attention. In this sense, it is fundamental to keep in mind the strengths and limitations of each analytical or imaging technique. At the end, the judicious application of the technique with the aim of supporting the search for answers to manifold questions arising during a long and painstaking path provides a continuous role for imaging within the complex area of drug discovery and development.
606   $aPharmacology$2bicssc
610   $acomputerized tomography(CT)
610   $aimaging
610   $amagnetic resonance imaging (MRI)
610   $amedical imaging
610   $apharmacology
610   $apositron emission tomography (PET)
610   $asingle photon emission computed tomography (SPECT)
610   $aultrasound
615  7$aPharmacology
700   $aNicolau Beckmann$4auth$01325198
702   $aAlbert D. Windhorst$4auth
702   $aIgor A. Kaltashov$4auth
906   $aBOOK
912   $a9910227348203321
996   $aIn Vivo Imaging in Pharmacological Research$93036674
997   $aUNINA