LEADER 02779nam 2200421z- 450 001 9910227347803321 005 20210211 035 $a(CKB)4100000000883855 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/52721 035 $a(oapen)doab52721 035 $a(EXLCZ)994100000000883855 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMapping Psychopathology with fMRI and Effective Connectivity Analysis 210 $cFrontiers Media SA$d2017 215 $a1 online resource (140 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-207-7 330 $aThere is a growing appreciation that many psychiatric (and neurological) conditions can be understood as functional disconnection syndromes - as reflected in aberrant functional integration and synaptic connectivity. This Research Topic considers recent advances in understanding psychopathology in terms of aberrant effective connectivity - as measured noninvasively using functional magnetic resonance imaging (fMRI). Recently, there has been increasing interest in inferring directed connectivity (effective connectivity) from fMRI data. Effective connectivity refers to the influence that one neural system exerts over another and quantifies the directed coupling among brain regions - and how they change with pathophysiology. Compared to functional connectivity, effective connectivity allows one to understand how brain regions interact with each other in terms of context sensitive changes and directed coupling - and therefore may provide mechanistic insights into the neural basis of psychopathology. Established models of effective connectivity include psychophysiological interaction (PPI), structural equation modeling (SEM) and dynamic causal modelling (DCM). DCM is unique because it explicitly models the interaction among brain regions in terms of latent neuronal activity. Moreover, recent advances in DCM such as stochastic and spectral DCM, make it possible to characterize the interaction between different brain regions both at rest and during a cognitive task. 606 $aNeurosciences$2bicssc 610 $abrain connectivity 610 $adynamic causal modeling 610 $aeffective connectivity 610 $afMRI 610 $aGranger causality analysis 610 $apsychophysiological interaction 615 7$aNeurosciences 700 $aBaojuan Li$4auth$01296688 702 $aAdeel Razi$4auth 702 $aKarl J. Friston$4auth 906 $aBOOK 912 $a9910227347803321 996 $aMapping Psychopathology with fMRI and Effective Connectivity Analysis$93024224 997 $aUNINA