LEADER 02620nam 2200469z- 450 001 9910227347103321 005 20210211 035 $a(CKB)4100000000883862 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42833 035 $a(oapen)doab42833 035 $a(EXLCZ)994100000000883862 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aThe CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation 210 $cFrontiers Media SA$d2017 215 $a1 online resource (100 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-223-9 330 $aThe neurodegenerative disorders such as Parkinson's disease (PD) or Alzheimer's disease (AD) are the most common forms of dementia and no pharmacological treatments are to date available for these diseases. Indeed, the only used drugs are symptomatic and no useful to block the progression of the diseases. The lack of a therapeutic approach is also due to a lack of an early diagnosis. This Research Topic describes a new target that is involved in the firs step of these disorders and that can be useful for the treatment and the diagnosis of such pathologies: the cannabinoid receptor subtype 2 or CB2R. Indeed, CB2R is overexpressed in reactive microglia and activated astrocytes during neuroinflammation and thus their detection by PET probes can be an easily strategy for an early diagnosis of neurodegeneration. Moreover, CB2 agonists and inverse agonists displayed neuroprotective effects and they so can be candidated as new therapeutich drugs for the treatment of these pathologies. Therefore, the aim of this Research Topic is to show the great potential of CB2R ligands for the development of new tools/drugs for both the therapy and the diagnosis of neurodegeneration. 517 $aCB2 Cannabinoid System 606 $aNeurosciences$2bicssc 610 $aAD 610 $aCannabinod system 610 $aCB2 receptor 610 $aCB2R agonist 610 $aCB2R inverse 610 $aInflammation 610 $aneurodegeneration 610 $aPD 615 7$aNeurosciences 700 $aMarialessandra Contino$4auth$01304687 702 $aNicola A. Colabufo$4auth 702 $aElena Capparelli$4auth 702 $aAshley I. Bush$4auth 906 $aBOOK 912 $a9910227347103321 996 $aThe CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation$93027605 997 $aUNINA